CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006548
UniProt Accession
Genbank Protein ID
 L10106 
Genbank Nucleotide ID
Protein Name
 Receptor-type tyrosine-protein phosphatase kappa 
Protein Synonyms/Alias
 Protein-tyrosine phosphatase kappa; R-PTP-kappa 
Gene Name
 Ptprk 
Gene Synonyms/Alias
 Ptpk 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1378KLILQVEKWQEECEEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. 
Sequence Annotation
 DOMAIN 30 193 MAM.
 DOMAIN 195 280 Ig-like C2-type.
 DOMAIN 290 382 Fibronectin type-III 1.
 DOMAIN 388 484 Fibronectin type-III 2.
 DOMAIN 489 588 Fibronectin type-III 3.
 DOMAIN 589 688 Fibronectin type-III 4.
 DOMAIN 899 1159 Tyrosine-protein phosphatase 1.
 DOMAIN 1191 1453 Tyrosine-protein phosphatase 2.
 REGION 1100 1106 Substrate binding (By similarity).
 ACT_SITE 1100 1100 Phosphocysteine intermediate (By
 ACT_SITE 1394 1394 Phosphocysteine intermediate (By
 BINDING 1068 1068 Substrate (By similarity).
 BINDING 1144 1144 Substrate (By similarity).
 CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
 CARBOHYD 139 139 N-linked (GlcNAc...).
 CARBOHYD 210 210 N-linked (GlcNAc...) (Potential).
 CARBOHYD 415 415 N-linked (GlcNAc...).
 CARBOHYD 423 423 N-linked (GlcNAc...) (Potential).
 CARBOHYD 435 435 N-linked (GlcNAc...) (Potential).
 CARBOHYD 461 461 N-linked (GlcNAc...).
 CARBOHYD 551 551 N-linked (GlcNAc...) (Potential).
 CARBOHYD 585 585 N-linked (GlcNAc...) (Potential).
 CARBOHYD 589 589 N-linked (GlcNAc...) (Potential).
 CARBOHYD 606 606 N-linked (GlcNAc...) (Potential).
 CARBOHYD 689 689 N-linked (GlcNAc...) (Potential).
 DISULFID 215 269 Potential.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Immunoglobulin domain; Membrane; Protein phosphatase; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1457 AA 
Protein Sequence
MDVAAAALPA FVALWLLYPW PLLGSALGQF SAGGCTFDDG PGACDYHQDL YDDFEWVHVS 60
AQEPHYLPPE MPQGSYMVVD SSNHDPGEKA RLQLPTMKEN DTHCIDFSYL LYSQKGLNPG 120
TLNILVRVNK GPLANPIWNV TGFTGRDWLR AELAVSTFWP NEYQVIFEAE VSGGRSGYIA 180
IDDIQVLSYP CDKSPHFLRL GDVEVNAGQN ATFQCIATGR DAVHNKLWLQ RRNGEDIPVA 240
QTKNINHRRF AASFRLQEVT KTDQDLYRCV TQSERGSGVS NFAQLIVREP PRPIAPPQLL 300
GVGPTYLLIQ LNANSIIGDG PIILKEVEYR MTSGSWTETH AVNAPTYKLW HLDPDTEYEI 360
RVLLTRPGEG GTGLPGPPLI TRTKCAEPMR TPKTLKIAEI QARRIAVDWE SLGYNITRCH 420
TFNVTICYHY FRGHNESRAD CLDMDPKAPQ HVVNHLPPYT NVSLKMILTN PEGRKESEET 480
IIQTDEDVPG PVPVKSLQGT SFENKIFLNW KEPLEPNGII TQYEVSYSSI RSFDPAVPVA 540
GPPQTVSNLW NSTHHVFMHL HPGTTYQFFI RASTVKGFGP ATAINVTTNI SAPSLPDYEG 600
VDASLNETAT TITVLLRPAQ AKGAPISAYQ IVVEQLHPHR TKREAGAMEC YQVPVTYQNA 660
LSGGAPYYFA AELPPGNLPE PAPFTVGDNR TYKGFWNPPL APRKGYNIYF QAMSSVEKET 720
KTQCVRIATK AAATEEPEVI PDPAKQTDRV VKIAGISAGI LVFILLLLVV IVIVKKSKLA 780
KKRKDAMGNT RQEMTHMVNA MDRSYADQST LHAEDPLSLT FMDQHNFSPR LPNDPLVPTA 840
VLDENHSATA ESSRLLDVPR YLCEGTESPY QTGQLHPAIR VADLLQHINL MKTSDSYGFK 900
EEYESFFEGQ SASWDVAKKD QNRAKNRYGN IIAYDHSRVI LQPVEDDPSS DYINANYIDI 960
WLYRDGYQRP SHYIATQGPV HETVYDFWRM VWQEQSACIV MVTNLVEVGR VKCYKYWPDD 1020
TEVYGDFKVT CVEMEPLAEY VVRTFTLERR GYNEIREVKQ FHFTGWPDHG VPYHATGLLS 1080
FIRRVKLSNP PSAGPIVVHC SAGAGRTGCY IVIDIMLDMA EREGVVDIYN CVKALRSRRI 1140
NMVQTEEQYI FIHDAILEAC LCGETAIPVC EFKAAYFDMI RIDSQTNSSH LKDEFQTLNS 1200
VTPRLQAEDC SIACLPRNHD KNRFMDMLPP DRCLPFLITI DGESSNYINA ALMDSYRQPA 1260
AFIVTQYPLP NTVKDFWRLV YDYGCTSIVM LNEVDLSQGC PQYWPEEGML RYGPIQVECM 1320
SCSMDCDVIN RIFRICNLTR PQEGYLMVQQ FQYLGWASHR EVPGSKRSFL KLILQVEKWQ 1380
EECEEGEGRT IIHCLNGGGR SGMFCAIGIV VEMVKRQNVV DVFHAVKTLR NSKPNMVEAP 1440
EQYRFCYDVA LEYLESS 1457 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031256; C:leading edge membrane; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0001750; C:photoreceptor outer segment; IDA:MGI.
 GO:0004725; F:protein tyrosine phosphatase activity; IDA:MGI.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0034614; P:cellular response to reactive oxygen species; IEA:Compara.
 GO:0034644; P:cellular response to UV; IEA:Compara.
 GO:0048041; P:focal adhesion assembly; IEA:Compara.
 GO:0045786; P:negative regulation of cell cycle; IEA:Compara.
 GO:0030336; P:negative regulation of cell migration; IEA:Compara.
 GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0034394; P:protein localization to cell surface; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Compara. 
Interpro
 IPR008985; ConA-like_lec_gl_sf.
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR000998; MAM_dom.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 
Pfam
 PF00041; fn3
 PF00629; MAM
 PF00102; Y_phosphatase 
SMART
 SM00060; FN3
 SM00409; IG
 SM00137; MAM
 SM00194; PTPc 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE
 PS00740; MAM_1
 PS50060; MAM_2
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS
 PR00020; MAMDOMAIN.
 PR00700; PRTYPHPHTASE.