| Tag | Content |
|---|
| CPLM ID | CPLM-017898 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Optineurin |
Protein Synonyms/Alias | FIP-2-like protein |
Gene Name | Optn |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 452 | QLQMDEMKQTIAKQE | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD) (By similarity). |
Sequence Annotation | REGION 416 525 Interaction with MYO6 (By similarity).
MOTIF 478 483 UBAN.
MOD_RES 188 188 Phosphoserine; by TBK1 (By similarity).
MOD_RES 219 219 Phosphoserine (By similarity).
MOD_RES 346 346 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Golgi apparatus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 585 AA |
Protein Sequence | MSHQPLSCLT EKGDSSCETP GNGPSNMVHP NLDTFTPEEL LQQMKELLVE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERQLFEIQS KEAKERLKAL SHENERLKEE LGKLKEKSER 120
PFEDITGRCG FPRTDLEQEV EQLKRQVEQE VEHLKIQVRR LQAEKADLLG IVSELQLKLN 180
SGGSSEDSFV EIRMTEGEAE GAMKEMRNSA GPTRTDSISM GKCTEDARTC VEFEELTVSQ 240
LLLCLREGNQ KVERLEIALR EAKERISDFE KKANGHSAIE TQTEGSTQKE EEDKDPESVG 300
IEVETLNVQV ASLFKELQEA HTKLSEAELM KKRLQEKCQA LERKNSATPS ELNEKQELVY 360
SNRKLELQVE SMRSEIKMEQ AKTEEEKSRL ATLQATHDKL LQEHNKALRT IEELTKQQAE 420
KVDKVQLQEL SEKLELAEQA LASKQLQMDE MKQTIAKQEE DLETMAVLRA QMEVYCSDFH 480
AERAAREKIH EEKEQLALQL AILLKENNDF EDGGSRQSLM EMQCRHGART SDSDQQAYLF 540
QRGAEDMSWQ HGQQPRSIPI HSCPKCGEVL PDIDTLQIHV MDCII 585 |
Gene Ontology | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:UniProtKB. GO:0005794; C:Golgi apparatus; IDA:UniProtKB. GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. GO:0005802; C:trans-Golgi network; ISS:UniProtKB. GO:0042802; F:identical protein binding; IDA:RGD. GO:0090161; P:Golgi ribbon formation; ISS:UniProtKB. GO:0051260; P:protein homooligomerization; IDA:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |