CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025998
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate dehydrogenase [NADP] 
Protein Synonyms/Alias
  
Gene Name
 GK2735 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Geobacillus kaustophilus (strain HTA426) 
NCBI Taxa ID
 235909 
Lysine Modification
Position
Peptide
Type
References
158YAGIEYAKGTPEVKKacetylation[1]
263RIVETEGKEAANKALacetylation[1]
356PKYAGLDKVNPSSVIacetylation[1]
Reference
 [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus.
 Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG.
 Proteomics. 2013 Aug;13(15):2278-82. [PMID: 23696451] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Glyoxylate bypass; Manganese; Metal-binding; NADP; Oxidoreductase; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MTQGEKITVQ NGVLNVPNNP IIPFIEGDGT GPDIWAAASR VLEAAVEKAY KGEKKIVWKE 60
VLAGEKAYKL TGSWLPDETL ETIREYIIAI KGPLTTPVGG GIRSLNVALR QELDLFVCLR 120
PVRYFPGVPS PVKRPEDTDM VIFRENTEDI YAGIEYAKGT PEVKKVIDFL QNEMGVRKIR 180
FPETSGIGIK PISEQGTKRL VRAAINYAIE HGRKSVTLVH KGNIMKFTEG AFKNWGYELA 240
EEEFADKVFT WAQYDRIVET EGKEAANKAL ADAEASGKII IKDVIADIFL QQILTRPREF 300
DVIATMNLNG DYISDALAAQ VGGIGIAPGA NINYETGHAI FEATHGTAPK YAGLDKVNPS 360
SVILSGVMMF EHLGWNEAAK LIIKAMEKTI AAKIVTYDFA RLMEGATEVK CSEFADALIR 420
NMD 423 
Gene Ontology
 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 
Interpro
 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR001804; Isocitrate/isopropylmalate_DH.
 IPR004439; Isocitrate_DH_NADP_dimer_prok.
 IPR024084; IsoPropMal-DH-like_dom. 
Pfam
 PF00180; Iso_dh 
SMART
  
PROSITE
 PS00470; IDH_IMDH 
PRINTS