UniProt Accession

 HMGA1_RAT; Q8K585; Q8K1F5 

Genbank Protein ID

 AF511040; AF507966 

Genbank Nucleotide ID

 AAM74157.1; AAM33433.1 

Protein Name

 High mobility group protein HMG-I/HMG-Y 

Protein Synonyms/Alias

 HMG-I(Y); High mobility group AT-hook protein 1; High mobility group protein A1 

Gene Name

 Hmga1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
35	RPRKQPSKEPSEVPT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity). 

Sequence Annotation

 DNA_BIND 21 31 A.T hook 1.
 DNA_BIND 53 63 A.T hook 2.
 DNA_BIND 78 89 A.T hook 3.
 REGION 53 77 Interaction with HIPK2 (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 15 15 N6-acetyllysine (By similarity).
 MOD_RES 26 26 Asymmetric dimethylarginine; alternate
 MOD_RES 26 26 Omega-N-methylarginine; alternate (By
 MOD_RES 26 26 Symmetric dimethylarginine; alternate (By
 MOD_RES 36 36 Phosphoserine; by HIPK2 and CDC2; in
 MOD_RES 39 39 Phosphothreonine (By similarity).
 MOD_RES 44 44 Phosphoserine (By similarity).
 MOD_RES 49 49 Phosphoserine (By similarity).
 MOD_RES 53 53 Phosphothreonine; by HIPK2 and CDC2; in
 MOD_RES 58 58 Asymmetric dimethylarginine; by PRMT6;
 MOD_RES 58 58 Omega-N-methylarginine; by PRMT6;
 MOD_RES 60 60 Asymmetric dimethylarginine; by PRMT6;
 MOD_RES 60 60 Omega-N-methylarginine; by PRMT6;
 MOD_RES 78 78 Phosphothreonine; by HIPK2 and CDC2; in
 MOD_RES 99 99 Phosphoserine (By similarity).
 MOD_RES 102 102 Phosphoserine (By similarity).
 MOD_RES 103 103 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Chromosome; Complete proteome; DNA-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 107 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0035985; C:senescence-associated heterochromatin focus; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; ISS:UniProtKB.
 GO:0042975; F:peroxisome proliferator activated receptor binding; ISS:UniProtKB.
 GO:0046965; F:retinoid X receptor binding; ISS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0090402; P:oncogene-induced senescence; ISS:UniProtKB.
 GO:2000774; P:positive regulation of cellular senescence; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0035986; P:senescence-associated heterochromatin focus assembly; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR020478; AT_hook-like.
 IPR017956; AT_hook_DNA-bd_motif.
 IPR000116; HMGI/HMGY.
 IPR000637; HMGI/Y_DNA-bd_CS. 

Pfam

 PF02178; AT_hook 

SMART

 SM00384; AT_hook 

PROSITE

 PS00354; HMGI_Y 

PRINTS

 PR00929; ATHOOK.
 PR00930; HIGHMOBLTYIY.