UniProt Accession

 RNQ1_YEAST; P25367; D6VQY7; Q8NKJ9; Q8TF94; Q8TFA2; Q8TFC8; Q8TFP4; Q8TFP5; Q8TFP6; Q8TFP7; Q8TFP8 

Genbank Protein ID

 M16717; X59720; AY028674; AY028675; AY028676; AY028677; AY028678; AY028679; AY028680; AY028681; AY028682; AY028683; AY028684; AY028685; BK006937 

Genbank Nucleotide ID

 AAA34615.1; CAC42958.1; AAK26208.1; AAK26209.1; AAK26210.1; AAK26211.1; AAK26212.1; AAK26213.1; AAK26214.1; AAK26215.1; AAK26216.1; AAK26217.1; AAK26218.1; AAK26219.1; DAA07456.1 

Protein Name

 [PIN+] prion protein RNQ1 

Protein Synonyms/Alias

 Rich in asparagine and glutamine protein 1 

Gene Name

 RNQ1 

Gene Synonyms/Alias

 YCL028W; YCL181; YCL28W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
5	***MDTDKLISEAES	acetylation	[1]
5	***MDTDKLISEAES	ubiquitination	[2, 3]
84	NTLMADSKGSSQTQL	ubiquitination	[2, 3]
107	VMTHSSNKGSSNRGF	ubiquitination	[2, 3]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Transferable epigenetic modifier which forms a prion responsible for the non-Mendelian trait [PIN+]. The native function of the soluble protein is unknown. 

Sequence Annotation

 REGION 153 402 Prion domain (PrD).
 MOD_RES 143 143 Phosphoserine.  

Keyword

 Amyloid; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Prion; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 405 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS