UniProt Accession

 1433T_RAT; P68255; P35216 

Genbank Protein ID

 D17614; BC062409 

Genbank Nucleotide ID

 BAA04533.1; AAH62409.1 

Protein Name

 14-3-3 protein theta 

Protein Synonyms/Alias

 14-3-3 protein tau 

Gene Name

 Ywhaq 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
9	EKTELIQKAKLAEQA	ubiquitination	[1]
49	NLLSVAYKNVVGGRR	acetylation	[2]
68	VISSIEQKTDTSDKK	acetylation	[2]
68	VISSIEQKTDTSDKK	ubiquitination	[1]
74	QKTDTSDKKLQLIKD	acetylation	[2]
85	LIKDYREKVESELRS	acetylation	[2]
115	NATNPESKVFYLKMK	acetylation	[2]
139	VACGDDRKQTIENSQ	ubiquitination	[1]
157	QEAFDISKKEMQPTH	acetylation	[2]
157	QEAFDISKKEMQPTH	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 3 3 N6-acetyllysine (By similarity).
 MOD_RES 49 49 N6-acetyllysine (By similarity).
 MOD_RES 68 68 N6-acetyllysine (By similarity).
 MOD_RES 115 115 N6-acetyllysine (By similarity).
 MOD_RES 232 232 Phosphoserine; by CK1 (Probable).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006605; P:protein targeting; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:Compara. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.