CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001007
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial import inner membrane translocase subunit Tim17-B 
Protein Synonyms/Alias
  
Gene Name
 TIMM17B 
Gene Synonyms/Alias
 TIM17B; JM3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
86GLVRLRGKEDPWNSIubiquitination[1, 2, 3, 4, 5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 172 AA 
Protein Sequence
MEEYAREPCP WRIVDDCGGA FTMGVIGGGV FQAIKGFRNA PVGIRHRLRG SANAVRIRAP 60
QIGGSFAVWG GLFSTIDCGL VRLRGKEDPW NSITSGALTG AVLAARSGPL AMVGSAMMGG 120
ILLALIEGVG ILLTRYTAQQ FRNAPPFLED PSQLPPKDGT PAPGYPSYQQ YH 172 
Gene Ontology
 GO:0031305; C:integral to mitochondrial inner membrane; IDA:BHF-UCL.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
 GO:0005744; C:mitochondrial inner membrane presequence translocase complex; IDA:BHF-UCL.
 GO:0015450; F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006626; P:protein targeting to mitochondrion; TAS:Reactome. 
Interpro
 IPR005678; Tim17.
 IPR003397; Tim17/Tim22/Tim23/PMP24. 
Pfam
 PF02466; Tim17 
SMART
  
PROSITE
  
PRINTS