UniProt Accession

 3HAO_RAT; P46953; P70474; Q5RKK0; Q64556 

Genbank Protein ID

 D44494; BC085739; D28339 

Genbank Nucleotide ID

 BAA07937.1; AAH85739.1; BAA21019.1 

Protein Name

 3-hydroxyanthranilate 3,4-dioxygenase 

Protein Synonyms/Alias

 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD 

Gene Name

 Haao 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
184	VMEPMSLKAWLESHS	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity). 

Sequence Annotation

 REGION 1 160 Domain A (catalytic) (By similarity).
 REGION 161 177 Linker (By similarity).
 REGION 178 286 Domain B (By similarity).
 METAL 47 47 Iron; catalytic (By similarity).
 METAL 53 53 Iron; catalytic (By similarity).
 METAL 91 91 Iron; catalytic (By similarity).
 BINDING 43 43 Dioxygen (By similarity).
 BINDING 53 53 Substrate (By similarity).
 BINDING 95 95 Substrate (By similarity).
 BINDING 105 105 Substrate (By similarity).
 MOD_RES 9 9 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Dioxygenase; Direct protein sequencing; Iron; Metal-binding; Oxidoreductase; Phosphoprotein; Pyridine nucleotide biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 286 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0031966; C:mitochondrial membrane; IDA:RGD.
 GO:0000334; F:3-hydroxyanthranilate 3,4-dioxygenase activity; IDA:RGD.
 GO:0008198; F:ferrous iron binding; IEA:HAMAP.
 GO:0005506; F:iron ion binding; IDA:RGD.
 GO:0019825; F:oxygen binding; IDA:RGD.
 GO:0043420; P:anthranilate metabolic process; IEA:HAMAP.
 GO:0034354; P:de novo NAD biosynthetic process from tryptophan; IEA:HAMAP.
 GO:0070050; P:neuron homeostasis; IEA:Compara.
 GO:0019805; P:quinolinate biosynthetic process; IEA:HAMAP.
 GO:0046874; P:quinolinate metabolic process; IDA:RGD.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0010043; P:response to zinc ion; IEA:Compara.
 GO:0006569; P:tryptophan catabolic process; IEA:HAMAP. 

Interpro

 IPR010329; 3hydroanth_dOase.
 IPR016700; 3hydroanth_dOase_met.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 

Pfam

 PF06052; 3-HAO 

SMART

  

PROSITE

  

PRINTS