| Tag | Content |
|---|
| CPLM ID | CPLM-020981 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | F-box only protein 3 |
Protein Synonyms/Alias | |
Gene Name | Fbxo3 |
Gene Synonyms/Alias | Fba; Fbx3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 68 | WLISEEEKAGKSQCW | ubiquitination | [1] | | 97 | IDHYAAIKKAWRDLK | ubiquitination | [1] | | 119 | PRMVLSLKEGAREED | ubiquitination | [1] | | 153 | YRIHNGQKLVVPGLL | ubiquitination | [1] | | 218 | EAAEGRNKNEVFYQC | ubiquitination | [1] | | 337 | YWRITNAKGDVEEVQ | ubiquitination | [1] | | 390 | HFLYFKDKVFNVAIP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation (By similarity). |
Sequence Annotation | DOMAIN 10 56 F-box.
DOMAIN 278 408 ApaG. |
Keyword | Alternative splicing; Complete proteome; Nucleus; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 480 AA |
Protein Sequence | MAAVEAETGL LTLESLPTDP LLLILSFVDY RDLINCCYVS RRLSQLSTHD PLWRRHCKKY 60
WLISEEEKAG KSQCWRSLFI ETYSDVGRYI DHYAAIKKAW RDLKKYLEPR CPRMVLSLKE 120
GAREEDLDAV EAQIGCKLPD DYRCSYRIHN GQKLVVPGLL GSMALSNHYR SEDLLDVDTA 180
AGGFQQRQGL KYCLPLTFCI HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI 240
IGATFTDWFT SYVNNVVSGG FPIIRDQIFR YIHDPECVAT TGDITVSVST SFLPELSSVH 300
PPHYFFTYRI RIEMSRDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG EFPIISPGRI 360
YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK VFNVAIPRFH MACPTFRVSI ARLEMGPDEY 420
EEMEEEAEEE EEEENDDSAD MDESDESDAD ENESDEGEGE ARRRRVFDVP IRRRRCSRLF 480 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |