| Tag | Content |
|---|
| CPLM ID | CPLM-021930 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Thioredoxin reductase 2, mitochondrial |
Protein Synonyms/Alias | Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3 |
Gene Name | TXNRD2 |
Gene Synonyms/Alias | KIAA1652; TRXR2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 303 | TRSLNLEKAGVDTSP | ubiquitination | [1] | | 314 | DTSPDTQKILVDSRE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. |
Sequence Annotation | NP_BIND 41 70 FAD (By similarity).
ACT_SITE 497 497 Proton acceptor (By similarity).
DISULFID 86 91 Redox-active (By similarity).
CROSSLNK 522 523 Cysteinyl-selenocysteine (Cys-Sec) (By |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; FAD; Flavoprotein; Mitochondrion; NADP; Oxidoreductase; Polymorphism; Redox-active center; Reference proteome; Selenocysteine; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 524 AA |
Protein Sequence | MEDQRGAAAG QRDYDLLVVG GGSGGLACAK EAAQLGRKVA VVDYVEPSPQ GTRWGLGGTC 60
VNVGCIPKKL MHQAALLGGL IQDAPNYGWE VAQPVPHDWR KMAEAVQNHV KSLNWGHRVQ 120
LQDRKVKYFN IKASFVDEHT VCGVAKGGKE ILLSADHIII ATGGRPRYPT HIEGALEYGI 180
TSDDIFWLKE SPGKTLVVGA SYVALECAGF LTGIGLDTTI MMRSIPLRGF DQQMSSMVIE 240
HMASHGTRFL RGCAPSRVRR LPDGQLQVTW EDSTTGKEDT GTFDTVLWAI GRVPDTRSLN 300
LEKAGVDTSP DTQKILVDSR EATSVPHIYA IGDVVEGRPE LTPIAIMAGR LLVQRLFGGS 360
SDLMDYDNVP TTVFTPLEYG CVGLSEEEAV ARHGQEHVEV YHAHYKPLEF TVAGRDASQC 420
YVKMVCLREP PQLVLGLHFL GPNAGEVTQG FALGIKCGAS YAQVMRTVGI HPTCSEEVVK 480
LRISKRSGLD PTVTGCUG 498 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:UniProtKB. GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. GO:0050661; F:NADP binding; IEA:InterPro. GO:0004791; F:thioredoxin-disulfide reductase activity; ISS:UniProtKB. GO:0045454; P:cell redox homeostasis; IEA:InterPro. GO:0007507; P:heart development; IEA:Compara. GO:0030097; P:hemopoiesis; IEA:Compara. GO:0000305; P:response to oxygen radical; TAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |