UniProt Accession

 BAP31_HUMAN; P51572; B3KQ79; D3DWV5; Q13836; Q96CF0 

Genbank Protein ID

 Z31696; X81109; X81817; AK057613; AK125631; U52111; CH471172; CH471172; CH471172; CH471172; CH471172; CH471172; CH471172; BC014323; BC065292; U36341 

Genbank Nucleotide ID

 CAA83501.1; CAA57015.1; CAA57415.1; BAG51941.1; BAG54226.1; EAW72818.1; EAW72819.1; EAW72820.1; EAW72821.1; EAW72823.1; EAW72824.1; EAW72825.1; AAH14323.1; AAH65292.1; AAA79508.1 

Protein Name

 B-cell receptor-associated protein 31 

Protein Synonyms/Alias

 BCR-associated protein 31; Bap31; 6C6-AG tumor-associated antigen; Protein CDM; p28 

Gene Name

 BCAP31 

Gene Synonyms/Alias

 BAP31; DXS1357E 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
146	KYDDVTEKVNLQNNP	ubiquitination	[1]
162	AMEHFHMKLFRAQRN	ubiquitination	[1, 2]
216	SASEAAKKYMEENDQ	ubiquitination	[2]
225	MEENDQLKKGAAVDG	ubiquitination	[2]
226	EENDQLKKGAAVDGG	ubiquitination	[2]
234	GAAVDGGKLDVGNAE	ubiquitination	[2]
243	DVGNAEVKLEEENRS	ubiquitination	[2]
252	EEENRSLKADLQKLK	ubiquitination	[2]
257	SLKADLQKLKDELAS	ubiquitination	[2]
259	KADLQKLKDELASTK	ubiquitination	[2]
271	STKQKLEKAENQVLA	ubiquitination	[1]
288	KQSEGLTKEYDRLLE	ubiquitination	[2]
310	AVDGPMDKKEE****	ubiquitination	[2]
311	VDGPMDKKEE*****	ubiquitination	[2]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis. 

Sequence Annotation

 MOTIF 243 246 Di-lysine motif.  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:Compara.
 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
 GO:0005811; C:lipid particle; IDA:UniProtKB.
 GO:0005102; F:receptor binding; NAS:UniProtKB.
 GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome.
 GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IMP:UniProtKB.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:UniProtKB.
 GO:0051561; P:elevation of mitochondrial calcium ion concentration; IMP:UniProtKB.
 GO:0006955; P:immune response; NAS:UniProtKB.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:0032471; P:reduction of endoplasmic reticulum calcium ion concentration; IMP:UniProtKB.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 

Interpro

 IPR008417; Bap31. 

Pfam

 PF05529; Bap31 

SMART

  

PROSITE

  

PRINTS