UniProt Accession

 MAGB2_HUMAN; O15479; O75860 

Genbank Protein ID

 U93163; AF015766; AC005185; BC026071 

Genbank Nucleotide ID

 AAC23617.1; AAD01565.1; AAD10635.1; AAH26071.1 

Protein Name

 Melanoma-associated antigen B2 

Protein Synonyms/Alias

 Cancer/testis antigen 3.2; CT3.2; DSS-AHC critical interval MAGE superfamily 6; DAM6; MAGE XP-2 antigen; MAGE-B2 antigen 

Gene Name

 MAGEB2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
80	AAGVSSTKSKKGAKS	ubiquitination	[1]
92	AKSHQGEKNASSSQA	ubiquitination	[1]
104	SQASTSTKSPSEDPL	ubiquitination	[1, 2]
114	SEDPLTRKSGSLVQF	ubiquitination	[3]
155	HFPEILKKASEGLSV	ubiquitination	[1]
170	VFGLELNKVNPNGHT	ubiquitination	[1]
250	EPWKLITKDLVQEKY	ubiquitination	[1, 2]
256	TKDLVQEKYLEYKQV	ubiquitination	[1, 2]
261	QEKYLEYKQVPSSDP	ubiquitination	[1, 2]
287	YAETSKMKVLEFLAK	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048] 

Functional Description

 May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. 

Sequence Annotation

 DOMAIN 111 310 MAGE.
 MOD_RES 77 77 Phosphoserine.
 MOD_RES 105 105 Phosphoserine.  

Keyword

 Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Tumor antigen; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 319 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR002190; MAGE.
 IPR021072; Melanoma_ass_antigen_N. 

Pfam

 PF01454; MAGE
 PF12440; MAGE_N 

SMART

  

PROSITE

 PS50838; MAGE 

PRINTS