UniProt Accession

 MTA3_HUMAN; Q9BTC8; Q9NSP2; Q9ULF4 

Genbank Protein ID

 AB033092; AK027304; BC004227; BC053631; AL161954 

Genbank Nucleotide ID

 BAA86580.1; BAB55028.1; AAH04227.1; AAH53631.1; CAB82305.1 

Protein Name

 Metastasis-associated protein MTA3 

Protein Synonyms/Alias

  

Gene Name

 MTA3 

Gene Synonyms/Alias

 KIAA1266 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	RRIEELNKTASGNVE	ubiquitination	[1]
426	PTQSEEEKLSPSPTT	ubiquitination	[1]
510	AAIRAECKMLLNS**	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. 

Sequence Annotation

 DOMAIN 1 147 BAH.
 DOMAIN 148 259 ELM2.
 DOMAIN 266 318 SANT.
 ZN_FING 379 406 GATA-type; atypical.
 MOD_RES 455 455 Phosphothreonine.
 MOD_RES 457 457 Phosphoserine.
 MOD_RES 519 519 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 594 AA 

Protein Sequence

Gene Ontology

 GO:0008278; C:cohesin complex; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016581; C:NuRD complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Compara. 

Interpro

 IPR001025; BAH_dom.
 IPR000949; ELM2_dom.
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom.
 IPR000679; Znf_GATA. 

Pfam

 PF01426; BAH
 PF01448; ELM2
 PF00320; GATA 

SMART

 SM00439; BAH
 SM00717; SANT
 SM00401; ZnF_GATA 

PROSITE

 PS51038; BAH
 PS51156; ELM2
 PS00344; GATA_ZN_FINGER_1
 PS50114; GATA_ZN_FINGER_2
 PS51293; SANT 

PRINTS