CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043641
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Inverted formin-2 
Protein Synonyms/Alias
  
Gene Name
 INF2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
33NPPTLRMKKLNWQKLubiquitination[1]
34PPTLRMKKLNWQKLPubiquitination[1]
39MKKLNWQKLPSNVARubiquitination[1, 2]
80LFSFPAAKPKEPTMVubiquitination[1, 3, 4]
141KFDVEVLKQLLKLLPubiquitination[1]
150LLKLLPEKHEIENLRubiquitination[1]
314EASSNLKKLLETERKubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 380 AA 
Protein Sequence
GMEEVIVAQV DHGLGSAWVP SHRRVNPPTL RMKKLNWQKL PSNVAREHNS MWASLSSPDA 60
EAVEPDFSSI ERLFSFPAAK PKEPTMVAPR ARKEPKEITF LDAKKSLNLN IFLKQFKCSN 120
EEVAAMIRAG DTTKFDVEVL KQLLKLLPEK HEIENLRAFT EERAKLASAD HFYLLLLAIP 180
CYQLRIECML LCEGAAAVLD MVRPKAQLVL AACESLLTSR QLPIFCQLIL RIGNFLNYGS 240
HTGDADGFKI STLLKLTETK SQQNRVTLLH HVLEEAEKSH PDLLQLPRDL EQPSQAAGIN 300
LEIIRSEASS NLKKLLETER KVSASVAEVQ EQYTERLQAT SRPSGHWMSC LRPSSRSNGS 360
WPTTCVRTPS SCPWRTRSAP 380 
Gene Ontology
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. 
Interpro
 IPR003104; Actin-bd_FH2/DRF_autoreg.
 IPR015425; FH2_actin-bd. 
Pfam
 PF02181; FH2 
SMART
 SM00498; FH2 
PROSITE
 PS51444; FH2 
PRINTS