UniProt Accession

 TXND9_HUMAN; O14530; B2R9G8; D3DVI4; Q53HG4; Q53RV8; Q6NSF5; Q9BRU6 

Genbank Protein ID

 AB006679; AK313777; CR456935; AK222616; AB451403; AC079447; CH471127; CH471127; BC005968; BC022864; BC070183 

Genbank Nucleotide ID

 BAA21881.1; BAG36515.1; CAG33216.1; BAD96336.1; BAG70217.1; AAX93257.1; EAX01869.1; EAX01870.1; AAH05968.1; AAH22864.1; AAH70183.2 

Protein Name

 Thioredoxin domain-containing protein 9 

Protein Synonyms/Alias

 ATP-binding protein associated with cell differentiation; Protein 1-4 

Gene Name

 TXNDC9 

Gene Synonyms/Alias

 APACD 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	HLDSEIQKLDQMDED	ubiquitination	[1]
62	LRKAQQQKQEWLSKG	ubiquitination	[1, 2]
87	RDFFQEVKESENVVC	ubiquitination	[2]
116	RHLAILSKKHLETKF	ubiquitination	[2]
117	HLAILSKKHLETKFL	ubiquitination	[2]
130	FLKLNVEKAPFLCER	ubiquitination	[2]
141	LCERLHIKVIPTLAL	ubiquitination	[3, 4]
150	IPTLALLKDGKTQDY	ubiquitination	[2]
153	LALLKDGKTQDYVVG	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin. 

Sequence Annotation

 DOMAIN 74 180 Thioredoxin.
 MOD_RES 188 188 Phosphoserine.
 MOD_RES 219 219 Phosphotyrosine (By similarity).
 MOD_RES 221 221 Phosphoserine.
 MOD_RES 223 223 Phosphoserine.  

Keyword

 Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro. 

Interpro

 IPR012336; Thioredoxin-like_fold.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS