UniProt Accession

 B4DXP3_HUMAN; B4DXP3 

Genbank Protein ID

 AC026202; AK302065 

Genbank Nucleotide ID

 BAG63455.1 

Protein Name

 ER degradation-enhancing alpha-mannosidase-like protein 1 

Protein Synonyms/Alias

 cDNA FLJ51559, highly similar to ER degradation-enhancingalpha-mannosidase-like 1 

Gene Name

 EDEM1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
84	LPAFENTKTGIPYPR	ubiquitination	[1, 2]
139	WVARRAVKALWNLRS	ubiquitination	[1]
333	LEKYTKVKCGYATLH	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 376 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IEA:InterPro. 

Interpro

 IPR001382; Glyco_hydro_47. 

Pfam

 PF01532; Glyco_hydro_47 

SMART

  

PROSITE

  

PRINTS

 PR00747; GLYHDRLASE47.