CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004530
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Purine-cytosine permease FCY2 
Protein Synonyms/Alias
 PCP FCY2; Cytosine/purine transport protein FCY2; Fluorocytosine resistance protein 2 
Gene Name
 FCY2 
Gene Synonyms/Alias
 YER056C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
16YEIQDLEKRSPVIGSubiquitination[1, 2]
29GSSLENEKKVAASETubiquitination[2]
30SSLENEKKVAASETFubiquitination[2]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 This permease has a broad specificity towards purines, and also transport cytosine and 5-methylcytosine but neither uracil nor thymine. 
Sequence Annotation
 REGION 165 184 Surface seeking (Potential).
 MOD_RES 18 18 Phosphoserine.  
Keyword
 Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 533 AA 
Protein Sequence
MLEEGNNVYE IQDLEKRSPV IGSSLENEKK VAASETFTAT SEDDQQYIVE SSEATKLSWF 60
HKFFASLNAE TKGVEPVTED EKTDDSILNA ASMWFSANMV IASYALGALG PMVFGLNFGQ 120
SVLVIIFFNI MGLIFVAFFS VFGAELGLRQ MILSRYLVGN VTARIFSLIN VIACVGWGIV 180
NTSVSAQLLN MVNEGSGHVC PIWAGCLIII GGTVLVTFFG YSVIHAYEKW SWVPNFAVFL 240
VIIAQLSRSG KFKGGEWVGG ATTAGSVLSF GSSIFGFAAG WTTYAADYTV YMPKSTNKYK 300
IFFSLVAGLA FPLFFTMILG AASAMAALND PTWKAYYDKN AMGGVIYAIL VPNSLNGFGQ 360
FCCVLLALST IANNIPNMYT VALSAQALWA PLAKIPRVVW TMAGNAATLG ISIPATYYFD 420
GFMENFMDSI GYYLAIYIAI SCSEHFFYRR SFSAYNIDDW DNWEHLPIGI AGTAALIVGA 480
FGVALGMCQT YWVGEIGRLI GKYGGDIGFE LGASWAFIIY NILRPLELKY FGR 533 
Gene Ontology
 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0015212; F:cytidine transmembrane transporter activity; IMP:SGD.
 GO:0015205; F:nucleobase transmembrane transporter activity; IDA:SGD.
 GO:0015856; P:cytosine transport; IDA:SGD.
 GO:0072530; P:purine-containing compound transmembrane transport; IDA:SGD. 
Interpro
 IPR001248; Cyt_pur_permease.
 IPR012681; NCS1.
 IPR026030; Pur-cyt_permease. 
Pfam
 PF02133; Transp_cyt_pur 
SMART
  
PROSITE
  
PRINTS