CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003761
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein GLI2 
Protein Synonyms/Alias
 Tax helper protein 
Gene Name
 GLI2 
Gene Synonyms/Alias
 THP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
757TPHTRNTKLPPLPGSacetylation[1]
Reference
 [1] Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy.
 Coni S, Antonucci L, D'Amico D, Di Magno L, Infante P, De Smaele E, Giannini G, Di Marcotullio L, Screpanti I, Gulino A, Canettieri G.
 PLoS One. 2013;8(6):e65718. [PMID: 23762415] 
Functional Description
 Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Is involved in the smoothened (SHH) signaling pathway. 
Sequence Annotation
 ZN_FING 437 464 C2H2-type 1.
 ZN_FING 475 497 C2H2-type 2; degenerate.
 ZN_FING 503 527 C2H2-type 3.
 ZN_FING 533 558 C2H2-type 4.
 ZN_FING 564 589 C2H2-type 5.
 MOD_RES 149 149 Phosphoserine.
 MOD_RES 234 234 Phosphoserine.
 MOD_RES 236 236 Phosphoserine.
 MOD_RES 242 242 Phosphoserine.
 MOD_RES 388 388 Phosphoserine; by DYRK2.
 MOD_RES 725 725 Phosphothreonine (By similarity).
 MOD_RES 1011 1011 Phosphoserine; by DYRK2.  
Keyword
 Activator; Alternative splicing; Complete proteome; Disease mutation; DNA-binding; Holoprosencephaly; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1586 AA 
Protein Sequence
METSASATAS EKQEAKSGIL EAAGFPDPGK KASPLVVAAA AAAAVAAQGV PQHLLPPFHA 60
PLPIDMRHQE GRYHYEPHSV HGVHGPPALS GSPVISDISL IRLSPHPAGP GESPFNAPHP 120
YVNPHMEHYL RSVHSSPTLS MISAARGLSP ADVAQEHLKE RGLFGLPAPG TTPSDYYHQM 180
TLVAGHPAPY GDLLMQSGGA ASAPHLHDYL NPVDVSRFSS PRVTPRLSRK RALSISPLSD 240
ASLDLQRMIR TSPNSLVAYI NNSRSSSAAS GSYGHLSAGA LSPAFTFPHP INPVAYQQIL 300
SQQRGLGSAF GHTPPLIQPS PTFLAQQPMA LTSINATPTQ LSSSSNCLSD TNQNKQSSES 360
AVSSTVNPVA IHKRSKVKTE PEGLRPASPL ALTQGQVSGH GSCGCALPLS QEQLADLKED 420
LDRDDCKQEA EVVIYETNCH WEDCTKEYDT QEQLVHHINN EHIHGEKKEF VCRWQACTRE 480
QKPFKAQYML VVHMRRHTGE KPHKCTFEGC SKAYSRLENL KTHLRSHTGE KPYVCEHEGC 540
NKAFSNASDR AKHQNRTHSN EKPYICKIPG CTKRYTDPSS LRKHVKTVHG PDAHVTKKQR 600
NDVHLRTPLL KENGDSEAGT EPGGPESTEA SSTSQAVEDC LHVRAIKTES SGLCQSSPGA 660
QSSCSSEPSP LGSAPNNDSG VEMPGTGPGS LGDLTALDDT PPGADTSALA APSAGGLQLR 720
KHMTTMHRFE QLKKEKLKSL KDSCSWAGPT PHTRNTKLPP LPGSGSILEN FSGSGGGGPA 780
GLLPNPRLSE LSASEVTMLS QLQERRDSST STVSSAYTVS RRSSGISPYF SSRRSSEASP 840
LGAGRPHNAS SADSYDPIST DASRRSSEAS QCSGGSGLLN LTPAQQYSLR AKYAAATGGP 900
PPTPLPGLER MSLRTRLALL DAPERTLPAG CPRPLGPRRG SDGPTYGHGH AGAAPAFPHE 960
APGGGARRAS DPVRRPDALS LPRVQRFHST HNVNPGPLPP CADRRGLRLQ SHPSTDGGLA 1020
RGAYSPRPPS ISENVAMEAV AAGVDGAGPE ADLGLPEDDL VLPDDVVQYI KAHASGALDE 1080
GTGQVYPTES TGFSDNPRLP SPGLHGQRRM VAADSNVGPS APMLGGCQLG FGAPSSLNKN 1140
NMPVQWNEVS SGTVDALASQ VKPPPFPQGN LAVVQQKPAF GQYPGYSPQG LQASPGGLDS 1200
TQPHLQPRSG APSQGIPRVN YMQQLRQPVA GSQCPGMTTT MSPHACYGQV HPQLSPSTIS 1260
GALNQFPQSC SNMPAKPGHL GHPQQTEVAP DPTTMGNRHR ELGVPDSALA GVPPPHPVQS 1320
YPQQSHHLAA SMSQEGYHQV PSLLPARQPG FMEPQTGPMG VATAGFGLVQ PRPPLEPSPT 1380
GRHRGVRAVQ QQLAYARATG HAMAAMPSSQ ETAEAVPKGA MGNMGSVPPQ PPPQDAGGAP 1440
DHSMLYYYGQ IHMYEQDGGL ENLGSCQVMR SQPPQPQACQ DSIQPQPLPS PGVNQVSSTV 1500
DSQLLEAPQI DFDAIMDDGD HSSLFSGALS PSLLHSLSQN SSRLTTPRNS LTLPSIPAGI 1560
SNMAVGDMSS MLTSLAEESK FLNMMT 1586 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0031512; C:motile primary cilium; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0007411; P:axon guidance; ISS:UniProtKB.
 GO:0048754; P:branching morphogenesis of an epithelial tube; ISS:UniProtKB.
 GO:0008283; P:cell proliferation; IDA:UniProtKB.
 GO:0071407; P:cellular response to organic cyclic compound; IEA:Compara.
 GO:0021696; P:cerebellar cortex morphogenesis; ISS:UniProtKB.
 GO:0090103; P:cochlea morphogenesis; IEA:Compara.
 GO:0048589; P:developmental growth; ISS:UniProtKB.
 GO:0048566; P:embryonic digestive tract development; ISS:UniProtKB.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0009913; P:epidermal cell differentiation; IDA:UniProtKB.
 GO:0021508; P:floor plate formation; ISS:UniProtKB.
 GO:0060322; P:head development; IEA:Compara.
 GO:0007507; P:heart development; ISS:UniProtKB.
 GO:0007442; P:hindgut morphogenesis; ISS:UniProtKB.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001822; P:kidney development; ISS:UniProtKB.
 GO:0030324; P:lung development; ISS:UniProtKB.
 GO:0030879; P:mammary gland development; ISS:UniProtKB.
 GO:0060603; P:mammary gland duct morphogenesis; IEA:Compara.
 GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
 GO:0060032; P:notochord regression; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; ISS:UniProtKB.
 GO:0002076; P:osteoblast development; ISS:UniProtKB.
 GO:0001649; P:osteoblast differentiation; IDA:UniProtKB.
 GO:0021983; P:pituitary gland development; ISS:UniProtKB.
 GO:0045740; P:positive regulation of DNA replication; IDA:UniProtKB.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0033089; P:positive regulation of T cell differentiation in thymus; ISS:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0060513; P:prostatic bud formation; IEA:Compara.
 GO:0009954; P:proximal/distal pattern formation; ISS:UniProtKB.
 GO:0008589; P:regulation of smoothened signaling pathway; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0001501; P:skeletal system development; ISS:UniProtKB.
 GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IEA:Compara.
 GO:0021938; P:smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; IEA:Compara.
 GO:0021776; P:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; IEA:Compara.
 GO:0021775; P:smoothened signaling pathway involved in ventral spinal cord interneuron specification; ISS:UniProtKB.
 GO:0021965; P:spinal cord ventral commissure morphogenesis; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS