Tag | Content |
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CPLM ID | CPLM-018529 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | L-xylulose reductase |
Protein Synonyms/Alias | XR; Dicarbonyl/L-xylulose reductase |
Gene Name | Dcxr |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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17 | ALVTGAGKGIGRSTV | ubiquitination | [1] | 171 | ALELGPHKIRVNAVN | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. |
Sequence Annotation | NP_BIND 11 39 NADP (By similarity). ACT_SITE 149 149 Proton acceptor (By similarity). ACT_SITE 153 153 By similarity. BINDING 136 136 Substrate (By similarity). MOD_RES 1 1 N-acetylmethionine (By similarity). |
Keyword | Acetylation; Carbohydrate metabolism; Cell membrane; Complete proteome; Glucose metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Xylose metabolism. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 244 AA |
Protein Sequence | MDLGLAGRRA LVTGAGKGIG RSTVLALKAA GAQVVAVSRT REDLDDLVRE CPGVEPVCVD 60 LADWEATEQA LSNVGPVDLL VNNAAVALLQ PFLEVTKEAC DTSFNVNLRA VIQVSQIVAK 120 GMIARGVPGA IVNVSSQASQ RALTNHTVYC STKGALDMLT KMMALELGPH KIRVNAVNPT 180 VVMTPMGRTN WSDPHKAKAM LDRIPLGKFA EVENVVDTIL FLLSNRSGMT TGSTLPVDGG 240 FLAT 244 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. GO:0005903; C:brush border; IDA:MGI. GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB. GO:0005902; C:microvillus; IDA:MGI. GO:0050038; F:L-xylulose reductase (NADP+) activity; IDA:UniProtKB. GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:Compara. GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW. GO:0006006; P:glucose metabolic process; IDA:UniProtKB. GO:0006739; P:NADP metabolic process; IDA:MGI. GO:0051289; P:protein homotetramerization; IDA:UniProtKB. GO:0005997; P:xylulose metabolic process; IDA:MGI. |
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