CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000132
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-glucose 6-dehydrogenase 
Protein Synonyms/Alias
 UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Protein sugarless; Protein suppenkasper 
Gene Name
 sgl 
Gene Synonyms/Alias
 kiwi; ska; CG10072 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
103KGRAADLKYVESAARacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues. 
Sequence Annotation
 NP_BIND 7 12 NAD (By similarity).
 NP_BIND 85 89 NAD (By similarity).
 NP_BIND 126 127 NAD (By similarity).
 NP_BIND 272 275 NAD (By similarity).
 REGION 157 161 Substrate binding (By similarity).
 REGION 216 223 Substrate binding (By similarity).
 REGION 256 269 Substrate binding (By similarity).
 REGION 334 335 Substrate binding (By similarity).
 ACT_SITE 272 272 Nucleophile (By similarity).
 BINDING 32 32 NAD (By similarity).
 BINDING 37 37 NAD (By similarity).
 BINDING 161 161 NAD (By similarity).
 BINDING 342 342 NAD (By similarity).
 BINDING 439 439 Substrate (By similarity).  
Keyword
 Complete proteome; NAD; Oxidoreductase; Reference proteome; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 476 AA 
Protein Sequence
MKVCCIGAGY VGGPTCAVMA LKCPDIVITL VDKSSERIAQ WNSDKLPIYE PGLDEVVKKC 60
RNVNLFFSTD IETAIKEADL IFISVNTPTK TCGNGKGRAA DLKYVESAAR MIAEIAQSNK 120
IVVEKSTVPV RAAESIMHIL RANQKPGIHY DILSNPEFLA EGTAINDLLN ADRVLIGGEE 180
TPEGHQAVEK LSWIYEHWIP KQNILTTNTW SSELSKLAAN AFLAQRISSI NSLSAVCEAT 240
GADVSEVARA VGLDSRIGSK FLQASVGFGG SCFQKDILNL IYICENLNLP EVAAYWQQVI 300
DMNEYQKRRF SQKIIESLFN TVSDKRIAIL GFAFKKNTGD TRETAAITVC QTLLEEGAAL 360
DIYDPKVEPE QIIDDLTHPS VTESPEKVKK AVQIHSDPYS AVRATHALVI CTEWDEFVDL 420
DFKRIYQSMM KPAYIFDGRK ILDHERLQQI GFHVQTIGKK YQRTGLLRSW GIVPQL 476 
Gene Ontology
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IMP:UniProtKB.
 GO:0030206; P:chondroitin sulfate biosynthetic process; IMP:UniProtKB.
 GO:0007427; P:epithelial cell migration, open tracheal system; IMP:UniProtKB.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; IMP:UniProtKB.
 GO:0007507; P:heart development; NAS:FlyBase.
 GO:0015014; P:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; IMP:UniProtKB.
 GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
 GO:0002121; P:inter-male aggressive behavior; IMP:FlyBase.
 GO:0007509; P:mesoderm migration involved in gastrulation; IMP:UniProtKB.
 GO:0016319; P:mushroom body development; IMP:FlyBase.
 GO:0042048; P:olfactory behavior; IMP:FlyBase.
 GO:0007428; P:primary branching, open tracheal system; TAS:FlyBase.
 GO:0007367; P:segment polarity determination; IMP:FlyBase.
 GO:0007224; P:smoothened signaling pathway; TAS:FlyBase.
 GO:0006065; P:UDP-glucuronate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0016055; P:Wnt receptor signaling pathway; TAS:FlyBase. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR016040; NAD(P)-bd_dom.
 IPR017476; Nucleotide_sugar_DH.
 IPR014027; UDP-Glc/GDP-Man_DH_C.
 IPR014026; UDP-Glc/GDP-Man_DH_dimer.
 IPR001732; UDP-Glc/GDP-Man_DH_N. 
Pfam
 PF00984; UDPG_MGDP_dh
 PF03720; UDPG_MGDP_dh_C
 PF03721; UDPG_MGDP_dh_N 
SMART
 SM00984; UDPG_MGDP_dh_C 
PROSITE
  
PRINTS