| Tag | Content |
|---|
| CPLM ID | CPLM-011199 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Fatty aldehyde dehydrogenase HFD1 |
Protein Synonyms/Alias | |
Gene Name | HFD1 |
Gene Synonyms/Alias | YMR110C; YM9718.09C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 225 | VGSIVAEKAAKSLTP | ubiquitination | [1] | | 250 | TFITENFKASNIKIA | ubiquitination | [1] | | 333 | INSTNGSKIVPSKIS | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. |
Sequence Annotation | NP_BIND 214 219 NAD (Potential).
ACT_SITE 236 236 By similarity.
ACT_SITE 273 273 By similarity.
MOD_RES 111 111 Phosphoserine. |
Keyword | Complete proteome; Endosome; Membrane; Mitochondrion; Mitochondrion outer membrane; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 532 AA |
Protein Sequence | MSNDGSKILN YTPVSKIDEI VEISRNFFFE KQLKLSHENN PRKKDLEFRQ LQLKKLYYAV 60
KDHEEELIDA MYKDFHRNKI ESVLNETTKL MNDILHLIEI LPKLIKPRRV SDSSPPFMFG 120
KTIVEKISRG SVLIIAPFNF PLLLAFAPLA AALAAGNTIV LKPSELTPHT AVVMENLLTT 180
AGFPDGLIQV VQGAIDETTR LLDCGKFDLI FYTGSPRVGS IVAEKAAKSL TPCVLELGGK 240
SPTFITENFK ASNIKIALKR IFFGAFGNSG QICVSPDYLL VHKSIYPKVI KECESVLNEF 300
YPSFDEQTDF TRMIHEPAYK KAVASINSTN GSKIVPSKIS INSDTEDLCL VPPTIVYNIG 360
WDDPLMKQEN FAPVLPIIEY EDLDETINKI IEEHDTPLVQ YIFSDSQTEI NRILTRLRSG 420
DCVVGDTVIH VGITDAPFGG IGTSGYGNYG GYYGFNTFSH ERTIFKQPYW NDFTLFMRYP 480
PNSAQKEKLV RFAMERKPWF DRNGNNKWGL RQYFSLSAAV ILISTIYAHC SS 532 |
Gene Ontology | GO:0005768; C:endosome; IDA:SGD. GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0031307; C:integral to mitochondrial outer membrane; IDA:SGD. GO:0005811; C:lipid particle; IDA:SGD. GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; ISS:SGD. GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:EC. GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro. GO:0047770; F:carboxylate reductase activity; IMP:SGD. GO:0006081; P:cellular aldehyde metabolic process; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |