| Tag | Content |
|---|
| CPLM ID | CPLM-016042 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rab3 GTPase-activating protein catalytic subunit |
Protein Synonyms/Alias | RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130; Rab3-GAP |
Gene Name | Rab3gap1 |
Gene Synonyms/Alias | Kiaa0066; Rab3gap |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 38 | EEVLNDWKLIGPSLG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; Cytoplasm; GTPase activation; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 981 AA |
Protein Sequence | MAADSEPESE VFEITDFTTA SEWERFISKV EEVLNDWKLI GPSLGKPLEK GIFTSGTWEE 60
RSDEISFADF RFSVTHHYLV QESPDKERKD EELEDAIPQS MQDLLCMNND FPPRAHCLVR 120
WYGLREFVVI APAAHSDAVL SESKCNLLLS SISIALGNTG CQVPLFVQIH HKWRRMYMGE 180
CQGPGVRTDF EMVHLRKVPS QYTHLSGLLD IFKSKIGCPL TPLPPVSIAI RLTYVLQDWQ 240
QYFWPQQPPD IDALVGGEVG GLEFGKLPFG ACEDPISELH LATTWPHLTE GIIVDNDVYS 300
DLDPVQAPHW SVRVRKADNP QCLLGDFVTE FLKICRRKES TDEILGRSTF EEEGREVADI 360
THALSKLTEP APVPIHKLSV SNMVHTAKKK IRKHRGEESP LNSDVLNTIL LFLFPDAVSE 420
KPLDGTTSID NSIPAPEAGD YTLYNQFKSA PSDSLTYKLA LCLCMINFYH GGLKGVAHLW 480
QEFVLEMRFR WENNFLIPGL ASGSPDLRCC LLHQKLQMLN CCIERKKARD EGKKTSLSDS 540
TTSAYPGDAG KTGGQLGLDH LRDTEKEKGE VGKSWDSWSD SEEEFFECLS DTEDLKGNGQ 600
ESGKKGGPKE MANLKPEGRL HQHGKLTLLH NGEPLYIPVT QEPAPMTEDL LEEQSEVLAK 660
LGTSAEGAHL RARMQSACLL SDMESFKAAN PGCFLEDFVR WYSPRDYIEE EVTDEKGNVV 720
LKGELSARMK IPSNMWVEAW ETAKPVPARR QRRLFDDTRE AEKVLHYLAM QKPADLARHL 780
LPCVIHAAVL KVKEEESLEN IPSVKKIIKQ IIAHSSKVLH FPNPEDKKLE EIILQITTVE 840
AIIARARSLK AKFGTEKCEH EEEKEGLERF VSCLLEQPEV SVTGAGRGHA GRIIHKLFVN 900
AQRAAAVALP EEELKKSGCP EERRQTLVSD FPPPAGRELI LRATVPRPAP YSKALPQRMY 960
SVLTKEDFRL AGAFSSDTSF F 981 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |