CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028000
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA polymerase 
Protein Synonyms/Alias
  
Gene Name
 DNApol-epsilon 
Gene Synonyms/Alias
 CG6768; Dmel_CG6768 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
15KVLQNTGKFVSENRTacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA replication; DNA-binding; DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2236 AA 
Protein Sequence
MSDSSKGKVL QNTGKFVSEN RTEGDDFFNE AGYRQSREND KIDSKYGFDR VKDSQERTGY 60
LINMHSNEVL DEDRRLIAAL DLFFIQMDGS RFKCTVAYQP YLLIRPEDNM HLEVARFLGR 120
KYSGQISGLE HITKEDLDLP NHLSGLQQQY IKLSFLNQTA MTKVRRELMS AVKRNQERQK 180
SNTYYMQMLA TSLAQSSAGS EDATLGKRQQ DYMDCIVDIR EHDVPYHVRV SIDLRIFCGQ 240
WYNIRCRSGV ELPTITCRPD ILDRPEPVVL AFDIETTKLP LKFPDAQTDQ VMMISYMIDG 300
QGYLITNREI ISSNVDDFEY TPKPEFEGNF IVFNEENEMQ LLQRFFDHIM EVRPHIIVTY 360
NGDFFDWPFV ETRAAVYDLD MKQEIGFSKL RDGNYLSRPA IHMDCLCWVK RDSYLPVGSQ 420
GLKAVAKAKL RYDPVELDPE DMCRMAVEQP QVLANYSVSD AVATYYLYMK YVHPFIFALN 480
TIIPMEPDEI LRKGSGTLCE TLLMVEAYHA QIVYPNKHQS ELNKLSNEGH VLDSETYVGG 540
HVEALESGVF RADIPCRFRL DPAMVKQLQE QVDAVLRHAI EVEEGIPLEK VLNLDEVRQE 600
IVQGLQGLHD IPNRLEQPVI YHLDVGAMYP NIILTNRLQP SAMVSDLDCA ACDFNKPGVR 660
CKRSMDWLWR GEMLPASRNE FQRIQQQLET EKFPPLFPGG PQRAFHELSK EDQAAYEKKR 720
LTDYCRKAYK KTKLTKLETR TSTICQKENS FYVDTVRAFR DRRYEYKGLT KVAKASVNAA 780
VASGDAAEIK AAKGREVLYD SLQLAHKCIL NSFYGYVMRR GARWHSMPMA GIVCLTGSNI 840
ITKAREIIER VGRPLELDTD GIWCILPGSF PQEFTIHTSH EKKKKINISY PNAVLNTMVK 900
DHFTNDQYHE LRKDKENNLP KYDIRDENSI FFEVDGPYLA MVLPAAKEEG KKLKKRYAVF 960
NFDGTLAELK GFEVKRRGEL QLIKNFQSSV FEAFLAGSTL EECYASVAKV ADYWLDVLYS 1020
RGSNLPDSEL FELISENKSM SKKLEEYGAQ KSTSISTAKR LAEFLGEQMV KDAGLACKYI 1080
ISKKPEGAPV TERAIPLAIF QSEPSVRRHH LRRWLKDNTM GDADIRDVLD WNYYIERLGG 1140
TIQKIITIPA ALQGLANPVP RVQHPDWLHK KMLEKNDVLK QRRINEMFTS RPKPKPLATE 1200
EDKLADMEDL AGKDGGEGAA GCPIVTKRKR IQLEEHDDEE AQPQATTWRQ ALGAPPPIGE 1260
TRKTIVEWVR FQKKKWKWQQ DQRQRNRQAS KRTRGEDPPV VRATGSTATL GGFLRRAQRT 1320
LLDQPWQIVQ LVPVDDLGHF TVWALIGEEL HKIKLTVPRI FYVNQRSAAP PEEGQLWRKV 1380
NRVLPRSRPV FNLYRYSVPE QLFRDNSLGM LADLATPDIE GIYETQMTLE FRALMDMGCI 1440
CGVQREEARR LAQLATKDLE TFSIEQLEQR PQTQVKYLAS ANNRLRKIYL YQHNTPTAKK 1500
EIWSLILMPS KKAFVFALDT VRANQMPNMR QLYTAERLAL LKNLTAEEQD KIPVEDYTFE 1560
VLIEVDVKQI YRHIQRALTT YKQEHQGPTI LCLQTALSAR KLSLAMPILL EFPQAEIHIS 1620
DDASLLSGLD WQRQGSRAVI RHFLNLNNVL DLMLDQCRYF HVPIGNMPPD TVLFGADLFF 1680
ARLLQRHNFV LWWSASTRPD LGGREADDSR LLAEFEESIS VVQNKAGFYP DVCVELALDS 1740
LAVSALLQST RIQEMEGASS AITFDVMPQV SLEEMIGTVP AATLPSYDET ALCSAAFRVM 1800
RSMVNGWLRE VSINRNIFSD FQIVHFYRWV RSSNALLYDP ALRRSLNNLM RKMFLRIIAE 1860
FKRLGATIIY ADFNRIILSS GKKTVSDALG YVDYIVQSLR NKEMFHSIQL SFEQCWNFML 1920
WMDQANFSGI RGKLPKGIDE TVSSIVSTTM IRDSERNQDD DEDEEEDSEN RDPVESNEAE 1980
QDQEDELSLE LNWTIGEHLP DENECREKFE SLLTLFMQSL AEKKTTEQAI KDISHCAFDF 2040
ILKLHKNYGK GKPSPGLELI RTLIKALSVD KTLAEQINEL RRNMLRLVGI GEFSDLAEWE 2100
DPCDSHIINE VICKACNHCR DLDLCKDKHR AMKDGVPVWL CAQCYVAYDN EEIEMRMLDA 2160
LQRKMMSYVL QDLRCSRCSE IKRENLAEFC TCAGNFVPLI SGKDIQTLLG TFNKVAANHK 2220
MQLLQQTVHQ ALTTPR 2236 
Gene Ontology
 GO:0008622; C:epsilon DNA polymerase complex; ISS:FlyBase.
 GO:0008296; F:3'-5'-exodeoxyribonuclease activity; IDA:FlyBase.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003887; F:DNA-directed DNA polymerase activity; IDA:FlyBase.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006281; P:DNA repair; IMP:FlyBase.
 GO:0006261; P:DNA-dependent DNA replication; IDA:FlyBase.
 GO:0007113; P:endomitotic cell cycle; IMP:FlyBase.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0035265; P:organ growth; IMP:FlyBase. 
Interpro
 IPR006172; DNA-dir_DNA_pol_B.
 IPR006133; DNA-dir_DNA_pol_B_exonuc.
 IPR006134; DNA-dir_DNA_pol_B_multi_dom.
 IPR013697; DNA_pol_e_suA_C.
 IPR012337; RNaseH-like_dom. 
Pfam
 PF00136; DNA_pol_B
 PF03104; DNA_pol_B_exo1
 PF08490; DUF1744 
SMART
 SM00486; POLBc 
PROSITE
  
PRINTS