CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038221
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Rasa1 
Protein Synonyms/Alias
  
Gene Name
 Rasa1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
283RAILPYTKVPDTDEIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTPase activation; Phosphoprotein; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1038 AA 
Protein Sequence
MMAAEAGSEE GGPATAGPGG GAATGSSAYS AACRVKLPAA LPVAAAPCPG LADADLVAAL 60
GGGAASGSGF LGTGPVAGVL GGAALTGSAA AGVAGAAAAG PAGDVAFTKG TLSLPAETLG 120
PGGGFPPLPP PPQLPPLGSG LGTVDEGDSL DGPEYEEEEV AIPLTAPPTN QWYHGKLDRT 180
IAEERLRQAG KSGSYLIRES DRRPGSFVLS FLSQTNVVNH FRIIAMCGDY YIGGRRFSSL 240
SDLIGYYSHV SCLLKGEKLL YPVAPPEPVE DRRRVRAILP YTKVPDTDEI SFLKGDMFIV 300
HNELEDGWMW VTNLRTDEQG LIVEDLVEEV GREEDPHEGK IWFHGKISKQ EAYNLLMTVG 360
QVCSFLVRPS DNTPGDYSLY FRTNENIQRF KICPTPNNQF MMGGRYYNSI GDIIDHYRKE 420
QIVEGYYLKE PVPMQDQGQV LNDTVDGKEI YNTIRRKTKD AFYKNIVKKG YLLKKGKGKR 480
WKNLYFILEG SDAQLIYFES EKRATKPKGL IDLSVCSVYV VHDSLFGRPN CFQIVVQHFS 540
EEHYIFYFAG ETPEQAEDWM KGLQAFCSLR KSSPGTSNKR LRQVSSLVLH IEEAHKLPVK 600
HFTNPYCNIY LNSVQVAKTH AREGQNPVWS EEFVFDDLPP DINRFEITLS NKTKKSKDPD 660
ILFMRCQLSR LQKGHATDEW FLLSSHIPLK GIEPGSLRVR ARYSMEKIMP EEEYSEFKEL 720
ILQKELHVVY ALSHVCGQDR TLLASILLKI FLHEKLESLL LCTLNDREIS MEDEATTLFR 780
ATTLASTLME QYMKATATQF VHHALKDSIL KIMESKQSCE LSPSKLEKNE DVNTNLAHLL 840
SILSELVEKI FMASEILPPT LRYIYGCLQK SVQHKWPTNN TMRTRVVSGF VFLRLICPAI 900
LNPRMFNIIS DSPSPIAART LTLVAKSVQN LANLVEFGAK EPYMEGVNPF IKSNKHRMIM 960
FLDELGNVPE LPDTTEHSRT DLSRDLAALH EICVAHSDEL RTLSNERGVQ QHVLKKLLAI 1020
TELLQQKQNQ YTKTNDIR 1038 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
 GO:0001726; C:ruffle; IDA:MGI.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
 GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Compara.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.
 GO:0030833; P:regulation of actin filament polymerization; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:Compara. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR001936; RasGAP.
 IPR023152; RasGAP_CS.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000980; SH2.
 IPR001452; SH3_domain. 
Pfam
 PF00168; C2
 PF00169; PH
 PF00616; RasGAP
 PF00017; SH2
 PF00018; SH3_1 
SMART
 SM00239; C2
 SM00233; PH
 SM00323; RasGAP
 SM00252; SH2
 SM00326; SH3 
PROSITE
 PS50004; C2
 PS50003; PH_DOMAIN
 PS00509; RAS_GTPASE_ACTIV_1
 PS50018; RAS_GTPASE_ACTIV_2
 PS50001; SH2
 PS50002; SH3 
PRINTS
 PR00401; SH2DOMAIN.