CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033758
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hyperpolarization-activated cation channel 2 
Protein Synonyms/Alias
  
Gene Name
 Hcn2 
Gene Synonyms/Alias
 hcn2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
99EGPARGPKVSFSCRGubiquitination[1]
150LLQPGVNKFSLRMFGubiquitination[1]
464EQYMSFHKLPADFRQubiquitination[1]
510IVNFNCRKLVASMPLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Ion channel; Ion transport; Membrane; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 863 AA 
Protein Sequence
MDARGGGGRP GDSPGTTPAP GPPPPPPPPA PPQPQPPPAP PPNPTTPSHP ESADESGPRA 60
RLCSRDSACT PGAAKGGANG ECGRGEPQCS PEGPARGPKV SFSCRGAASG PSAAEEAGSE 120
EAGPAGEPRG SQASFLQRQF GALLQPGVNK FSLRMFGSQK AVEREQERVK SAGAWIIHPY 180
SDFRFYWDFT MLLFMVGNLI IIPVGITFFK DETTAPWIVF NVVSDTFFLM DLVLNFRTGI 240
VIEDNTEIIL DPEKIKKKYL RTWFVVDFVS SIPVDYIFLI VEKGIDSEVY KTARALRIVR 300
FTKILSLLRL LRLSRLIRYI HQWEEIFHMT YDLASAVMRI CNLISMMLLL CHWDGCLQFL 360
VPMLQDFPSD CWVSINNMVN HSWSELYSFA LFKAMSHMLC IGYGRQAPES MTDIWLTMLS 420
MIVGATCYAM FIGHATALIQ SLDSSRRQYQ EKYKQVEQYM SFHKLPADFR QKIHDYYEHR 480
YQGKMFDEDS ILGELNGPLR EEIVNFNCRK LVASMPLFAN ADPNFVTAML TKLKFEVFQP 540
GDYIIREGTI GKKMYFIQHG VVSVLTKGNK EMKLSDGSYF GEICLLTRGR RTASVRADTY 600
CRLYSLSVDN FNEVLEEYPM MRRAFETVAI DRLDRIGKKN SILLHKVQHD LSSGVFNNQE 660
NAIIQEIVKY DREMVQQAEL GQRVGLFPPP PPPQVTSAIA TLQQAVAMSF CPQVARPLVG 720
PLALGSPRLV RRAPPGPLPP AASPGPPAAS PPAAPSSPRA PRTSPYGVPG SPATRVGPAL 780
PARRLSRASR PLSASQPSLP HGVPAPSPAA SARPASSSTP RLGPAPTART AAPSPDRRDS 840
ASPGAASGLD PLDSARSRLS SNL 863 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
 GO:0042391; P:regulation of membrane potential; IDA:MGI. 
Interpro
 IPR018490; cNMP-bd-like.
 IPR018488; cNMP-bd_CS.
 IPR000595; cNMP-bd_dom.
 IPR005821; Ion_trans_dom.
 IPR013621; Ion_trans_N.
 IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
 IPR014710; RmlC-like_jellyroll. 
Pfam
 PF00027; cNMP_binding
 PF00520; Ion_trans
 PF08412; Ion_trans_N 
SMART
 SM00100; cNMP 
PROSITE
 PS00888; CNMP_BINDING_1
 PS50042; CNMP_BINDING_3 
PRINTS
 PR01463; EAGCHANLFMLY.