| Tag | Content |
|---|
| CPLM ID | CPLM-008284 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Steryl-sulfatase |
Protein Synonyms/Alias | Arylsulfatase C; ASC; Steroid sulfatase; Steryl-sulfate sulfohydrolase |
Gene Name | Sts |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 376 | NGVFRGGKGNNWEGG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Conversion of sulfated steroid precursors to estrogens during pregnancy. |
Sequence Annotation | ACT_SITE 144 144 By similarity.
METAL 43 43 Calcium (By similarity).
METAL 44 44 Calcium (By similarity).
METAL 83 83 Calcium; via 3-oxoalanine (By
METAL 350 350 Calcium (By similarity).
METAL 351 351 Calcium (By similarity).
MOD_RES 83 83 3-oxoalanine (Cys) (By similarity).
CARBOHYD 55 55 N-linked (GlcNAc...) (Potential).
CARBOHYD 465 465 N-linked (GlcNAc...) (Potential).
DISULFID 149 156 By similarity.
DISULFID 178 250 By similarity.
DISULFID 454 495 By similarity.
DISULFID 487 493 By similarity. |
Keyword | Calcium; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Lipid metabolism; Membrane; Metal-binding; Microsome; Pregnancy; Reference proteome; Signal; Steroid metabolism; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 624 AA |
Protein Sequence | MPRPRPLLLA VMAATLADII LAADPAPAGP APRPPNFLLI MADDLGIGDL GCYGNKTLRT 60
PHLDRLAREG VKLTQHLAAA PLCTPSRAAF LTGRYPPRSG MAAHGRVGVY LFTASSGGLP 120
PSEVTMARLL KGRGYATALI GKWHLGLSCR GATDFCHHPL RHGFDRFLGV PTTNLRDCRP 180
GAGTVFGPAL RVFAAGPLAA LGASLAAMAA ARWAGLARVP GWALAGTAAA MLAVGGPRSA 240
SCLGFRPANC FLMDDLAVAQ RPTDYGGLTR RLADEAALFL RRNRARPFLL FLSFLHVHTA 300
HFADPGFAGR SLHGAYGDSV EEMDWGVGRV LAALDELGLA RETLVYFTSD HGAHVEELGP 360
RGERMGGSNG VFRGGKGNNW EGGVRVPCLV RWPRELSPGR VVAEPTSLMD VFPTVARLAG 420
AELPGDRVID GRDLMPLLRG DAQRSEHEFL FHYCNAYLQA VRWHNGSAVW KAFYFTPNFA 480
PAGANGCFST HVCLCAGPAH VTAHDPPLLF DLTRDPGERR PLTPEAEPRH REVLDAIDAA 540
ARAHRARLRP APDQLAPRHL MWKPWLQLWG GGGAGGGAGA QDDSGHAHGD GSHAHDDPGH 600
AQDRGDDDAH YGGHATTRTQ ATPR 624 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004773; F:steryl-sulfatase activity; IEA:EC. GO:0008484; F:sulfuric ester hydrolase activity; ISO:MGI. GO:0007565; P:female pregnancy; IEA:UniProtKB-KW. GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |