UniProt Accession

 H4_MEDSA; P62789; P02308; P59258 

Genbank Protein ID

  

Genbank Nucleotide ID

  

Protein Name

 Histone H4 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Medicago sativa (Alfalfa) 

NCBI Taxa ID

 3879 

Lysine Modification

Position	Peptide	Type	References
6	**MSGRGKGGKGLGK	acetylation	[1]
9	SGRGKGGKGLGKGGA	acetylation	[1]
13	KGGKGLGKGGAKRHR	acetylation	[1]
17	GLGKGGAKRHRKVLR	acetylation	[1]
21	GGAKRHRKVLRD***	acetylation	[1]

Reference

 [1] Identification of five sites of acetylation in alfalfa histone H4.
 Waterborg JH.
 Biochemistry. 1992 Jul 14;31(27):6211-9. [PMID: 1627562] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 DNA_BIND 17 21
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 6 6 N6-acetyllysine.
 MOD_RES 9 9 N6-acetyllysine.
 MOD_RES 13 13 N6-acetyllysine.
 MOD_RES 17 17 N6-acetyllysine.
 MOD_RES 21 21 N6-acetyllysine.  

Keyword

 Acetylation; Chromosome; Direct protein sequencing; DNA-binding; Nucleosome core; Nucleus. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 25 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR001951; Histone_H4.
 IPR019809; Histone_H4_CS. 

Pfam

  

SMART

  

PROSITE

 PS00047; HISTONE_H4 

PRINTS

 PR00623; HISTONEH4.