CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022682
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alcohol dehydrogenase 4 
Protein Synonyms/Alias
 ADH2; Alcohol dehydrogenase class II; Alcohol dehydrogenase II 
Gene Name
 Adh4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
99PFFAPQCKRCKLCLSubiquitination[1]
102APQCKRCKLCLSPLTubiquitination[1]
114PLTNLCGKLRNFKYPubiquitination[1]
119CGKLRNFKYPTIDQEubiquitination[1]
238GEKFPKAKALGATDCubiquitination[1]
326GTFFGGWKSVDSVPNubiquitination[1]
339PNLVSDYKNKKFDLDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the reduction of benzoquinones. 
Sequence Annotation
 NP_BIND 204 209 NAD.
 NP_BIND 297 299 NAD.
 NP_BIND 320 322 NAD.
 METAL 47 47 Zinc 1; catalytic.
 METAL 68 68 Zinc 1; catalytic.
 METAL 98 98 Zinc 2.
 METAL 101 101 Zinc 2.
 METAL 104 104 Zinc 2.
 METAL 112 112 Zinc 2.
 METAL 179 179 Zinc 1; catalytic.
 BINDING 49 49 NAD.
 BINDING 228 228 NAD.
 BINDING 233 233 NAD.
 BINDING 372 372 NAD.
 MOD_RES 30 30 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Metal-binding; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MGTQGKVIKC KAAIAWKTGS PLCIEEIEVS PPKACEVRIQ VIATCVCPTD INATDPKKKA 60
LFPVVLGHEC AGIVESVGPG VTNFKPGDKV IPFFAPQCKR CKLCLSPLTN LCGKLRNFKY 120
PTIDQELMED RTSRFTCKGR SIYHFMGVSS FSQYTVVSEA NLARVDDEAN LERVCLIGCG 180
FSSGYGAAIN TAKVTPSSTC AVFGLGCVGL SAIIGCKIAG ASRIIAIDIN GEKFPKAKAL 240
GATDCLNPRE LDKPVQDVIT ELTAGGVDYS LDCAGTAQTL KAAVDCTVLG WGSCTVVGAK 300
VDKMTIPTVD VILGRSINGT FFGGWKSVDS VPNLVSDYKN KKFDLDLLVT HALPFESIND 360
AIDLMKEGKS IRTILTF 377 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0004024; F:alcohol dehydrogenase activity, zinc-dependent; IDA:MGI.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:MGI.
 GO:0005503; F:all-trans retinal binding; IEA:Compara.
 GO:0019115; F:benzaldehyde dehydrogenase activity; IEA:Compara.
 GO:0051287; F:NAD binding; IEA:Compara.
 GO:0003960; F:NADPH:quinone reductase activity; IDA:MGI.
 GO:0019841; F:retinol binding; IEA:Compara.
 GO:0004745; F:retinol dehydrogenase activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0046164; P:alcohol catabolic process; IDA:MGI.
 GO:0006081; P:cellular aldehyde metabolic process; IDA:MGI.
 GO:0006067; P:ethanol metabolic process; IDA:MGI.
 GO:0006069; P:ethanol oxidation; IEA:Compara.
 GO:0042375; P:quinone cofactor metabolic process; IDA:MGI.
 GO:0042572; P:retinol metabolic process; IEA:Compara. 
Interpro
 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF08240; ADH_N
 PF00107; ADH_zinc_N 
SMART
  
PROSITE
 PS00059; ADH_ZINC 
PRINTS