UniProt Accession

 B4DGU4_HUMAN; B4DGU4 

Genbank Protein ID

 AC104307; AK294778 

Genbank Nucleotide ID

 BAG57905.1 

Protein Name

 Catenin beta-1 

Protein Synonyms/Alias

 cDNA FLJ57878, highly similar to Beta-catenin 

Gene Name

 CTNNB1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	MAMEPDRKAAVSHWQ	ubiquitination	[1, 2, 3, 4, 5]
126	AEPSQMLKHAVVNLI	acetylation	[6]
126	AEPSQMLKHAVVNLI	ubiquitination	[2, 3, 4, 5, 7]
151	RAIPELTKLLNDEDQ	ubiquitination	[1, 2, 3, 4, 5]
163	EDQVVVNKAAVMVHQ	ubiquitination	[1, 2, 3, 4, 5, 8]
173	VMVHQLSKKEASRHA	ubiquitination	[3, 5]
174	MVHQLSKKEASRHAI	ubiquitination	[4]
226	EGLLAIFKSGGIPAL	ubiquitination	[1, 2, 3, 5]
274	RLAGGLQKMVALLNK	ubiquitination	[5]
328	MRTYTYEKLLWTTSR	ubiquitination	[1, 2, 3, 5]
338	WTTSRVLKVLSVCSS	ubiquitination	[3, 4]
347	LSVCSSNKPAIVEAG	ubiquitination	[2, 3, 4, 9]
428	TCNNYKNKMMVCQVG	ubiquitination	[3, 4, 5, 8]
489	YGLPVVVKLLHPPSH	ubiquitination	[3]
501	PSHWPLIKATVGLIR	ubiquitination	[2, 3, 4, 5, 8, 9]
618	LCELAQDKEAAEAIE	ubiquitination	[2]
664	EDKPQDYKKRLSVEL	ubiquitination	[2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [7] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [8] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [9] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 774 AA 

Protein Sequence

Gene Ontology

 GO:0043296; C:apical junction complex; IEA:Compara.
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0071664; C:catenin-TCF7L2 complex; IEA:Compara.
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043198; C:dendritic shaft; IEA:Compara.
 GO:0005916; C:fascia adherens; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0016328; C:lateral plasma membrane; IEA:Compara.
 GO:0031528; C:microvillus membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0034750; C:Scrib-APC-beta-catenin complex; IEA:Compara.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0009948; P:anterior/posterior axis specification; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0045453; P:bone resorption; IEA:Compara.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Compara.
 GO:0061324; P:canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; IEA:Compara.
 GO:0001708; P:cell fate specification; IEA:Compara.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0016337; P:cell-cell adhesion; IEA:Compara.
 GO:0007160; P:cell-matrix adhesion; IEA:Compara.
 GO:0034613; P:cellular protein localization; IEA:Compara.
 GO:0071407; P:cellular response to organic cyclic compound; IEA:Compara.
 GO:0022009; P:central nervous system vasculogenesis; IEA:Compara.
 GO:0009950; P:dorsal/ventral axis specification; IEA:Compara.
 GO:0007398; P:ectoderm development; IEA:Compara.
 GO:0000578; P:embryonic axis specification; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0048617; P:embryonic foregut morphogenesis; IEA:Compara.
 GO:0035115; P:embryonic forelimb morphogenesis; IEA:Compara.
 GO:0035050; P:embryonic heart tube development; IEA:Compara.
 GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Compara.
 GO:0036023; P:embryonic skeletal limb joint morphogenesis; IEA:Compara.
 GO:0001711; P:endodermal cell fate commitment; IEA:Compara.
 GO:0060742; P:epithelial cell differentiation involved in prostate gland development; IEA:Compara.
 GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Compara.
 GO:0030900; P:forebrain development; IEA:Compara.
 GO:0061198; P:fungiform papilla formation; IEA:Compara.
 GO:0001702; P:gastrulation with mouth forming second; IEA:Compara.
 GO:0035112; P:genitalia morphogenesis; IEA:Compara.
 GO:0007403; P:glial cell fate determination; IEA:Compara.
 GO:0031069; P:hair follicle morphogenesis; IEA:Compara.
 GO:0060789; P:hair follicle placode formation; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0002089; P:lens morphogenesis in camera-type eye; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0060479; P:lung cell differentiation; IEA:Compara.
 GO:0060492; P:lung induction; IEA:Compara.
 GO:0060484; P:lung-associated mesenchyme development; IEA:Compara.
 GO:0030539; P:male genitalia development; IEA:Compara.
 GO:0060916; P:mesenchymal cell proliferation involved in lung development; IEA:Compara.
 GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Compara.
 GO:0007494; P:midgut development; IEA:Compara.
 GO:0045445; P:myoblast differentiation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Compara.
 GO:0048715; P:negative regulation of oligodendrocyte differentiation; IEA:Compara.
 GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0072079; P:nephron tubule formation; IEA:Compara.
 GO:0001840; P:neural plate development; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0048599; P:oocyte development; IEA:Compara.
 GO:0030316; P:osteoclast differentiation; IEA:Compara.
 GO:0060066; P:oviduct development; IEA:Compara.
 GO:0031016; P:pancreas development; IEA:Compara.
 GO:0001569; P:patterning of blood vessels; IEA:Compara.
 GO:0061047; P:positive regulation of branching involved in lung morphogenesis; IEA:Compara.
 GO:2000017; P:positive regulation of determination of dorsal identity; IEA:Compara.
 GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Compara.
 GO:0060769; P:positive regulation of epithelial cell proliferation involved in prostate gland development; IEA:Compara.
 GO:0045743; P:positive regulation of fibroblast growth factor receptor signaling pathway; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0043410; P:positive regulation of MAPK cascade; IEA:Compara.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Compara.
 GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Compara.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0009954; P:proximal/distal pattern formation; IEA:Compara.
 GO:0070602; P:regulation of centromeric sister chromatid cohesion; IEA:Compara.
 GO:0031641; P:regulation of myelination; IEA:Compara.
 GO:0072182; P:regulation of nephron tubule epithelial cell differentiation; IEA:Compara.
 GO:0003266; P:regulation of secondary heart field cardioblast proliferation; IEA:Compara.
 GO:0042129; P:regulation of T cell proliferation; IEA:Compara.
 GO:0072053; P:renal inner medulla development; IEA:Compara.
 GO:0072054; P:renal outer medulla development; IEA:Compara.
 GO:0072033; P:renal vesicle formation; IEA:Compara.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0014010; P:Schwann cell proliferation; IEA:Compara.
 GO:0043588; P:skin development; IEA:Compara.
 GO:0051145; P:smooth muscle cell differentiation; IEA:Compara.
 GO:0050808; P:synapse organization; IEA:Compara.
 GO:0048489; P:synaptic vesicle transport; IEA:Compara.
 GO:0033077; P:T cell differentiation in thymus; IEA:Compara.
 GO:0048538; P:thymus development; IEA:Compara.
 GO:0060440; P:trachea formation; IEA:Compara. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo.
 IPR013284; Beta-catenin. 

Pfam

 PF00514; Arm 

SMART

 SM00185; ARM 

PROSITE

 PS50176; ARM_REPEAT 

PRINTS

 PR01869; BCATNINFAMLY.