UniProt Accession

 KMO_MOUSE; Q91WN4 

Genbank Protein ID

 AK129011; BC014683 

Genbank Nucleotide ID

 AAH14683.1 

Protein Name

 Kynurenine 3-monooxygenase 

Protein Synonyms/Alias

 Kynurenine 3-hydroxylase 

Gene Name

 Kmo 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
78	LEDQIVSKGVPMKAR	ubiquitination	[1]
102	SAIPYGNKSQYILSI	acetylation	[2]
102	SAIPYGNKSQYILSI	ubiquitination	[1]
116	ISRENLNKDLLTAVE	acetylation	[2]
116	ISRENLNKDLLTAVE	ubiquitination	[1]
135	AKVHFGHKLSKCIPE	acetylation	[2]
138	HFGHKLSKCIPEEGV	acetylation	[2]
138	HFGHKLSKCIPEEGV	ubiquitination	[1]
153	LTVLGPDKVPRDVTC	acetylation	[2]
179	TVRAHLMKKPRFDYT	acetylation	[2]
180	VRAHLMKKPRFDYTQ	acetylation	[2]
289	AQPMISVKCSPFHLK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (By similarity). 

Sequence Annotation

 MOD_RES 399 399 Phosphothreonine.  

Keyword

 Alternative splicing; Complete proteome; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Monooxygenase; NADP; Oxidoreductase; Phosphoprotein; Pyridine nucleotide biosynthesis; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 479 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:HAMAP.
 GO:0004502; F:kynurenine 3-monooxygenase activity; ISS:UniProtKB.
 GO:0016174; F:NAD(P)H oxidase activity; IEA:Compara.
 GO:0043420; P:anthranilate metabolic process; IEA:HAMAP.
 GO:0034354; P:de novo NAD biosynthetic process from tryptophan; IEA:HAMAP.
 GO:0019674; P:NAD metabolic process; ISS:UniProtKB.
 GO:0019805; P:quinolinate biosynthetic process; IEA:HAMAP.
 GO:0009651; P:response to salt stress; IEA:Compara.
 GO:0019441; P:tryptophan catabolic process to kynurenine; IEA:Compara. 

Interpro

 IPR027545; Kynurenine_monooxygenase.
 IPR002938; mOase_FAD-bd.
 IPR003042; Rng_hydrolase-like. 

Pfam

 PF01494; FAD_binding_3 

SMART

  

PROSITE

  

PRINTS

 PR00420; RNGMNOXGNASE.