UniProt Accession

 B4DEX5_HUMAN; B4DEX5 

Genbank Protein ID

 AL035417; AL390776; AK293833; CH471059 

Genbank Nucleotide ID

 BAG57236.1; EAX07045.1 

Protein Name

 ERI1 exoribonuclease 3 

Protein Synonyms/Alias

 Prion protein interacting protein, isoform CRA_d; cDNA FLJ60449, highly similar to Homo sapiens prion protein interacting protein (PRNPIP), mRNA 

Gene Name

 PRNPIP 

Gene Synonyms/Alias

 ERI3; hCG_25206 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	RVDEWMAKEGLLDPN	ubiquitination	[1, 2]
99	FKQWINLKKAYSFAM	ubiquitination	[2]
144	KNIANIMKTLAYRGF	ubiquitination	[1, 3]
154	AYRGFIFKQTSKPF*	ubiquitination	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Amyloid; Complete proteome; Prion; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 160 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004527; F:exonuclease activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 

Interpro

 IPR006055; Exonuclease.
 IPR013520; Exonuclease_RNaseT/DNA_pol3.
 IPR012337; RNaseH-like_dom. 

Pfam

 PF00929; RNase_T 

SMART

 SM00479; EXOIII 

PROSITE

  

PRINTS