CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017466
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cleavage and polyadenylation specificity factor subunit 7 
Protein Synonyms/Alias
 Cleavage and polyadenylation specificity factor 59 kDa subunit; CFIm59; CPSF 59 kDa subunit; Pre-mRNA cleavage factor Im 59 kDa subunit 
Gene Name
 CPSF7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
191LLELLPGKVLNGEKVubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3' processing. Binds to cleavage and polyadenylation RNA substrates. 
Sequence Annotation
 DOMAIN 82 162 RRM.
 MOD_RES 203 203 Phosphothreonine.
 MOD_RES 413 413 Phosphoserine.
 MOD_RES 423 423 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; mRNA processing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 471 AA 
Protein Sequence
MGRPESAGGG SRGPFEGGGR ARRAGGIFLT LSILRTRDLP SGAMSEGVDL IDIYADEEFN 60
QDPEFNNTDQ IDLYDDVLTA TSQPSDDRSS STEPPPPVRQ EPSPKPNNKT PAILYTYSGL 120
RNRRAAVYVG SFSWWTTDQQ LIQVIRSIGV YDVVELKFAE NRANGQSKGY AEVVVASENS 180
VHKLLELLPG KVLNGEKVDV RPATRQNLSQ FEAQARKREC VRVPRGGIPP RAHSRDSSDS 240
ADGRATPSEN LVPSSARVDK PPSVLPYFNR PPSALPLMGL PPPPIPPPPP LSSSFGVPPP 300
PPGIHYQHLM PPPPRLPPHL AVPPPGAIPP ALHLNPAFFP PPNATVGPPP DTYMKASAPY 360
NHHGSRDSGP PPSTVSEAEF EDIMKRNRAI SSSAISKAVS GASAGDYSDA IETLLTAIAV 420
IKQSRVANDE RCRVLISSLK DCLHGIEAKS YSVGASGSSS RKRHRSRERS PSRSRESSRR 480
HRDLLHNEDR HDDYFQERNR EHERHRDRER DRHH 514 
Gene Ontology
 GO:0005849; C:mRNA cleavage factor complex; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0031124; P:mRNA 3'-end processing; TAS:Reactome.
 GO:0000398; P:mRNA splicing, via spliceosome; TAS:Reactome.
 GO:0051262; P:protein tetramerization; IDA:UniProtKB.
 GO:0006369; P:termination of RNA polymerase II transcription; TAS:Reactome. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS