CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042422
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 
Protein Synonyms/Alias
  
Gene Name
 INPP5D 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
400SEGELVVKFGETLPKubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 810 AA 
Protein Sequence
KREGFCQLLQ QMKNKHSEQP EPDMITIFIG TWNMGNAPPP KKITSWFLSK GQGKTRDDSA 60
DYIPHDIYVI GTQEDPLSEK EWLEILKHSL QEITSVTFKT VAIHTLWNIR IVVLAKPEHE 120
NRISHICTDN VKTGIANTLG NKGAVGVSFM FNGTSLGFVN SHLTSGSEKK LRRNQNYMNI 180
LRFLALGDKK LSPFNITHRF THLFWFGDLN YRVDLPTWEA ETIIQKIKQQ QYADLLSHDQ 240
LLTERREQKV FLHFEEEEIT FAPTYRFERL TRDKYAYTKQ KATGMKYNLP SWCDRVLWKS 300
YPLVHVVCQS YGSTSDIMTS DHSPVFATFE AGVTSQFVSK NGPGTVDSQG QIEFLRCYAT 360
LKTKSQTKFY LEFHSSCLES FVKSQEGENE EGSEGELVVK FGETLPKLKP IISDPEYLLD 420
QHILISIKSS DSDESYGEGC IALRLEATET QLPIYTPLTH HGELTGHFQG EIKLQTSQGK 480
TREKLYDFVK TERDESSGPK TLKSLTSHDP MKQWEVTSRA PPCSGSSITE IINPNYMGVG 540
PFGPPMPLHV KQTLSPDQQP TAWSYDQPPK DSPLGPCRGE SPPTPPGQPP ISPKKFLPST 600
ANRGLPPRTQ ESRPSDLGKN AGDTLPQEDL PLTKPEMFEN PLYGSLSSFP KPAPRKDQES 660
PKMPRKEPPP CPEPGILSPS IVLTKAQEAD RGEGPGKQVP APRLRSFTCS SSAEGRAAGG 720
DKSQGKPKTP VSSQAPVPAK RPIKPSRSEI NQQTPPTPTP RPPLPVKSPA VLHLQHSKGR 780
DYRDNTELPH HGKHRPEEGP PGPLGRTAMQ 810 
Gene Ontology
 GO:0005622; C:intracellular; IEA:Compara.
 GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:Compara.
 GO:0034594; F:phosphatidylinositol trisphosphate phosphatase activity; IEA:Compara.
 GO:0008340; P:determination of adult lifespan; IEA:Compara.
 GO:0016064; P:immunoglobulin mediated immune response; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:Compara.
 GO:0030889; P:negative regulation of B cell proliferation; IEA:Compara.
 GO:0045779; P:negative regulation of bone resorption; IEA:Compara.
 GO:0050777; P:negative regulation of immune response; IEA:Compara.
 GO:0045409; P:negative regulation of interleukin-6 biosynthetic process; IEA:Compara.
 GO:0045656; P:negative regulation of monocyte differentiation; IEA:Compara.
 GO:0045659; P:negative regulation of neutrophil differentiation; IEA:Compara.
 GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Compara.
 GO:0009968; P:negative regulation of signal transduction; IEA:Compara.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0045579; P:positive regulation of B cell differentiation; IEA:Compara.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Compara. 
Interpro
 IPR005135; Endo/exonuclease/phosphatase.
 IPR000300; IPPc. 
Pfam
 PF03372; Exo_endo_phos 
SMART
 SM00128; IPPc 
PROSITE
  
PRINTS