CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015783
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FAST kinase domain-containing protein 5 
Protein Synonyms/Alias
  
Gene Name
 FASTKD5 
Gene Synonyms/Alias
 KIAA1792 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
82HPGLEFSKTSSSKASubiquitination[1]
87FSKTSSSKASTLQLGubiquitination[1, 2, 3, 4]
361RSLVNIVKMFRFTHVubiquitination[5]
507RLAQERTKFDLLKELacetylation[6, 7]
615TPAENVAKLRLEHVGubiquitination[5]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [7] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773
Functional Description
  
Sequence Annotation
 DOMAIN 697 757 RAP.
 MOD_RES 95 95 Phosphoserine.
 MOD_RES 507 507 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 764 AA 
Protein Sequence
MAATLKSLKL VRYRAFCSPS AFGAVRSVSY WNVSSTQHGG QDPPEHISLC HSAKKVKNIC 60
STFSSRRILT TSSAHPGLEF SKTSSSKAST LQLGSPRATG VDEEDVEVFD SFENMRVFLQ 120
LRPEYRVHSY NASETSQLLS VSEGELILHK VRVNQNNLQA QVIVDYLCKL SSLPAEQHPV 180
LLGSTSFALL CQLSVKKIQL FDTQDLINVL KAFVILGIPH SHSMLDVYET KCCHQVWEMN 240
MDQLLLVADL WRYLGRKVPR FLNIFSSYLN LHWKDLSLSQ LVHLIYVIGE NRQVSQDLMQ 300
KLESLILKYI DLINLEEVGT ICLGFFKSST NLSEFVMRKI GDLACANIQH LSSRSLVNIV 360
KMFRFTHVDH INFMKQIGEI APQRIPSLGV QGVMHLTLYC SALRFLNEGV MNAVAASLPP 420
RVAHCRSKDV AKILWSFGTL NYKPPNAEEF YSSLISEIHR KMPEFNQYPE HLPTCLLGLA 480
FLEYFPVELI DFALSPGFVR LAQERTKFDL LKELYTLDGT VGIECPDYRG NRLSTHLQQE 540
GSELLWYLAE KDMNSKPEFL ETVFLLETML GGPQYVKHHM ILPHTRSSDL EVQLDVNLKP 600
LPFNREATPA ENVAKLRLEH VGVSLTDDLM NKLLKGKARG HFQGKTESEP GQQPMELENK 660
AAVPLGGFLC NVADKSGAME MAGLCPAACM QTPRMKLAVQ FTNRNQYCYG SRDLLGLHNM 720
KRRQLARLGY RVVELSYWEW LPLLKRTRLE KLAFLHEKVF TSAL 764 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0045333; P:cellular respiration; ISS:UniProtKB.
 GO:0006468; P:protein phosphorylation; IEA:GOC. 
Interpro
 IPR013579; FAST_2.
 IPR010622; FAST_Leu-rich.
 IPR013584; RAP. 
Pfam
 PF06743; FAST_1
 PF08368; FAST_2
 PF08373; RAP 
SMART
 SM00952; RAP 
PROSITE
 PS51286; RAP 
PRINTS