CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019098
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dedicator of cytokinesis protein 10 
Protein Synonyms/Alias
 Zizimin-3 
Gene Name
 DOCK10 
Gene Synonyms/Alias
 KIAA0694; ZIZ3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
255VQNNRLRKYAFELKMubiquitination[1]
349TETEDTVKTTRNMERubiquitination[1]
370DPDIDTLKLQKKDLLubiquitination[1]
384LEPESVIKPFEEKAAubiquitination[1]
489GLPEEWLKFPKQAVFubiquitination[1]
528SGAEPYIKNPDSNKYubiquitination[1]
834KHGGSDIKWVDGGKPacetylation[2]
954SYIKFVFKTRACKERubiquitination[1]
1593LLYFFMRKNFEFNKQacetylation[2]
1920LLKLYADKFGADNVKubiquitination[1]
1989PFTLSGKKHGGVAEQubiquitination[1]
2120DVNERLIKEDQLEYQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861
Functional Description
 Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. 
Sequence Annotation
 DOMAIN 181 290 PH.
 DOMAIN 672 850 DHR-1.
 DOMAIN 1690 2150 DHR-2.
 MOD_RES 834 834 N6-acetyllysine.
 MOD_RES 1232 1232 Phosphoserine.
 MOD_RES 1292 1292 Phosphoserine.
 MOD_RES 1295 1295 Phosphoserine.
 MOD_RES 1318 1318 Phosphoserine.
 MOD_RES 1440 1440 Phosphothreonine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2186 AA 
Protein Sequence
MAGERTRRFT RSLLRPGQAA ELRHSAASAA AVAVSSRQQQ RQEKPRLLEP LDYETVIEEL 60
EKTYRNDPLQ DLLFFPSDDF SAATVSWDIR TLYSTVPEDA EHKAENLLVK EACKFYSSQW 120
HVVNYKYEQY SGDIRQLPRA EYKPEKLPSH SFEIDHEDAD KDEDTTSHSS SKGGGGAGGT 180
GVFKSGWLYK GNFNSTVNNT VTVRSFKKRY FQLTQLPDNS YIMNFYKDEK ISKEPKGCIF 240
LDSCTGVVQN NRLRKYAFEL KMNDLTYFVL AAETESDMDE WIHTLNRILQ ISPEGPLQGR 300
RSTELTDLGL DSLDNSVTCE CTPEETDSSE NNLHADFAKY LTETEDTVKT TRNMERLNLF 360
SLDPDIDTLK LQKKDLLEPE SVIKPFEEKA AKRIMIICKA LNSNLQGCVT ENENDPITNI 420
EPFFVSVALY DLRDSRKISA DFHVDLNHAA VRQMLLGASV ALENGNIDTI TPRQSEEPHI 480
KGLPEEWLKF PKQAVFSVSN PHSEIVLVAK IEKVLMGNIA SGAEPYIKNP DSNKYAQKIL 540
KSNRQFCSKL GKYRMPFAWA VRSVFKDNQG NVDRDSRFSP LFRQESSKIS TEDLVKLVSD 600
YRRADRISKM QTIPGSLDIA VDNVPLEHPN CVTSSFIPVK PFNMMAQTEP TVEVEEFVYD 660
STKYCRPYRV YKNQIYIYPK HLKYDSQKCF NKARNITVCI EFKNSDEESA KPLKCIYGKP 720
GGPLFTSAAY TAVLHHSQNP DFSDEVKIEL PTQLHEKHHI LFSFYHVTCD INAKANAKKK 780
EALETSVGYA WLPLMKHDQI ASQEYNIPIA TSLPPNYLSF QDSASGKHGG SDIKWVDGGK 840
PLFKVSTFVV STVNTQDPHV NAFFQECQKR EKDMSQSPTS NFIRSCKNLL NVEKIHAIMS 900
FLPIILNQLF KVLVQNEEDE ITTTVTRVLT DIVAKCHEEQ LDHSVQSYIK FVFKTRACKE 960
RTVHEELAKN VTGLLKSNDS TTVKHVLKHS WFFFAIILKS MAQHLIDTNK IQLPRPQRFP 1020
ESYQNELDNL VMVLSDHVIW KYKDALEETR RANHSVARFL KRCFTFMDRG YVFKMVNNYI 1080
SMFSSGDLKT LCQYKFDFLQ EVCQHEHFIP LCLPIRSANI PDPLTPSEST QELHASDMPE 1140
YSVTNEFCRK HFLIGILLRE VGFALQEDQD VRHLALAVLK NLMAKHSFDD RYREPRKQAQ 1200
IASLYMPLYG MLLDNMPRIY LKDLYPFTVN TSNQGSRDDL STNGGFQSQT AIKHANSVDT 1260
SFSKDVLNSI AAFSSIAIST VNHADSRASL ASLDSNPSTN EKSSEKTDNC EKIPRPLSLI 1320
GSTLRFDKLD QAETRSLLMC FLHIMKTISY ETLIAYWQRA PSPEVSDFFS ILDVCLQNFR 1380
YLGKRNIIRK IAAAFKFVQS TQNNGTLKGS NPSCQTSGLL SQWMHSTSSH EGHKQHRSQT 1440
LPIIRGKNAL SNPKLLQMLD NTMTSNSNEI DIVHHVDTEA NIATEVCLTI LDLLSLFTQT 1500
HQRQLQQCDC QNSLMKRVFD TYMLFFQVNQ SATALKHVFA SLRLFVCKFP SAFFQGPADL 1560
CGSFCYEVLK CCNHRSRSTQ TEASALLYFF MRKNFEFNKQ KSIVRSHLQL IKAVSQLIAD 1620
AGIGGSRFQH SLAITNNFAN GDKQMKNSNF PAEVKDLTKR IRTVLMATAQ MKEHEKDPEM 1680
LVDLQYSLAN SYASTPELRR TWLESMAKIH ARNGDLSEAA MCYIHIAALI AEYLKRKGYW 1740
KVEKICTASL LSEDTHPCDS NSLLTTPSGG SMFSMGWPAF LSITPNIKEE GAMKEDSGMQ 1800
DTPYNENILV EQLYMCVEFL WKSERYELIA DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY 1860
LKVAEVVNSE KRLFGRYYRV AFYGQGFFEE EEGKEYIYKE PKLTGLSEIS QRLLKLYADK 1920
FGADNVKIIQ DSNKVNPKDL DPKYAYIQVT YVTPFFEEKE IEDRKTDFEM HHNINRFVFE 1980
TPFTLSGKKH GGVAEQCKRR TILTTSHLFP YVKKRIQVIS QSSTELNPIE VAIDEMSKKV 2040
SELNQLCTME EVDMIRLQLK LQGSVSVKVN AGPMAYARAF LEETNAKKYP DNQVKLLKEI 2100
FRQFADACGQ ALDVNERLIK EDQLEYQEEL RSHYKDMLSE LSTVMNEQIT GRDDLSKRGV 2160
DQTCTRVISK ATPALPTVSI SSSAEV 2186 
Gene Ontology
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR010703; DOCK_C.
 IPR021816; DOCK_C/D_N.
 IPR026796; DOCK_D.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2
 PF11878; DUF3398
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2
 PS50003; PH_DOMAIN 
PRINTS