CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015177
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family F member 1 
Protein Synonyms/Alias
  
Gene Name
 Abcf1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
332GLVGPNGKGKTTLLKubiquitination[1]
339KGKTTLLKHIANRALacetylation[2]
403GDDTAAEKLEKVYEEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity). 
Sequence Annotation
 DOMAIN 296 540 ABC transporter 1.
 DOMAIN 617 832 ABC transporter 2.
 NP_BIND 328 335 ATP 1 (By similarity).
 NP_BIND 650 657 ATP 2 (By similarity).
 MOD_RES 22 22 Phosphoserine (By similarity).
 MOD_RES 103 103 Phosphoserine.
 MOD_RES 107 107 Phosphoserine; by CK2.
 MOD_RES 138 138 Phosphoserine; by CK2.
 MOD_RES 194 194 Phosphoserine.
 MOD_RES 587 587 Phosphoserine (By similarity).
 CROSSLNK 565 565 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 574 574 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Activator; ATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 837 AA 
Protein Sequence
MPKGPKQQPP EPEWIGDGEG TSPADKVVKK GKKDKKTKKT FFEELAVEDK QAGEEEKLQK 60
EKEQQQQQQQ QKKKRDTRKG RRKKDVDDDS DERVLMERLK QLSVPASDEE DEVPAPIPRG 120
RKKAKGGNVF EALIQDDSEE EEEEEENRVL KPAKPEKNRI NKAVAEEPPG LRSKKGKEEK 180
SKGKAKSKPA AADSEGEEEE EDTAKEKEPP QQGKDRDKKE AEQGSGEEKE EKEGDLKAND 240
PYANLSKKEK KKLKKQMDYE RQVESLKAAN AAENDFSVSQ AEVSSRQAML ENASDIKLEK 300
FSISAHGKEL FVNADLYIVA GRRYGLVGPN GKGKTTLLKH IANRALSIPP NIDVLLCEQE 360
VVADETPAVQ AVLRADTKRL RLLEEERRLQ GQLEQGDDTA AEKLEKVYEE LRATGAAAAE 420
AKARRILAGL GFDPEMQNRP TQKFSGGWRM RVSLARALFM EPTLLMLDEP TNHLDLNAVI 480
WLNNYLQGWR KTLLIVSHDQ GFLDDVCTDI IHLDTQRLHY YRGNYMTFKK MYQQKQKELL 540
KQYEKQEKKL KELKAGGKST KQAEKQTKEV LTRKQQKCRR KNQDEESQEP PELLKRPKEY 600
TVRFTFPDPP PLSPPVLGLH GVTFGYEGQK PLFKNLDFGI DMDSRICIVG PNGVGKSTLL 660
LLLTGKLTPT NGEMRKNHRL KIGFFNQQYA EQLHMEETPT EYLQRSFNLP YQDARKCLGR 720
FGLESHAHTI QICKLSGGQK ARVVFAELAC REPDVLILDE PTNNLDIESI DALGEAINDY 780
KGAVIVVSHD ARLITETNCQ LWVVEEQGVS QIDGDFDDYK REVLEALGEV MVNRPRD 837 
Gene Ontology
 GO:0005635; C:nuclear envelope; ISS:UniProtKB.
 GO:0005654; C:nucleoplasm; ISS:UniProtKB.
 GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0043022; F:ribosome binding; ISS:UniProtKB.
 GO:0008494; F:translation activator activity; ISS:UniProtKB.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0006413; P:translational initiation; ISS:UniProtKB. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS