CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005323
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cyclin-dependent kinase 11B 
Protein Synonyms/Alias
 Cell division cycle 2-like protein kinase 1; Cell division protein kinase 11; Cyclin-dependent kinase 11; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1 
Gene Name
 Cdk11b 
Gene Synonyms/Alias
 Cdc2l1; Cdk11 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
553WILHRDLKTSNLLLSubiquitination[1]
630QKPLFPGKSDIDQINubiquitination[1]
638SDIDQINKIFKDLGTubiquitination[1]
649DLGTPSEKIWPGYNDubiquitination[1]
662NDLPAVKKMTFSEYPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Acts as a negative regulator of the normal cell cycle progression. In vitro, this protein kinase has been shown to phosphorylate a number of substrates, including histone h1, casein, and galactosyltransferase. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase. 
Sequence Annotation
 DOMAIN 427 712 Protein kinase.
 NP_BIND 433 441 ATP (By similarity).
 ACT_SITE 551 551 Proton acceptor (By similarity).
 BINDING 456 456 ATP (By similarity).
 MOD_RES 47 47 Phosphoserine.
 MOD_RES 115 115 Phosphoserine (By similarity).
 MOD_RES 264 264 Phosphoserine.
 MOD_RES 270 270 Phosphoserine.
 MOD_RES 471 471 Phosphoserine; by CDK7 (By similarity).
 MOD_RES 477 477 Phosphothreonine; by CDK7 (By
 MOD_RES 578 578 Phosphoserine (By similarity).
 MOD_RES 583 583 Phosphotyrosine (By similarity).
 MOD_RES 584 584 Phosphothreonine (By similarity).
 MOD_RES 740 740 Phosphothreonine.
 MOD_RES 741 741 Phosphoserine.  
Keyword
 Alternative initiation; ATP-binding; Cell cycle; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 784 AA 
Protein Sequence
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHRMEI 60
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR KDEKRKEKRR HRSHSAEGGK 120
HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH SRRERDRLEQ LERKRERERK 180
LREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE EYSDKGKVGH WSRSPLRPPR 240
ERFEMGDNRK PVKEEKVEER DLLSDLQDIS DSERKTSSAE SSSAESGSGS EEEEEEEEEE 300
EEEEGSTSEE SEEEEEEEEE EEEEETGSNS EEASEQSAEE VSDEEMSEDE DRENENHILV 360
VPESRFDRDS GDSEEGEEEV GEGTPQSSAP TEGDYVPDSP ALSPIELKQE LPKYLPALQG 420
CRSVEEFQCL NRIEEGTYGV VYRAKDKKTD EIVALKRLKM EKEKEGFPIT SLREINTILK 480
AQHPNIVTVR EIVVGSNMDK IYIVMNYVEH DLKSLMETMK QPFLPGEVKT LMIQLLSGVK 540
HLHDNWILHR DLKTSNLLLS HAGILKVGDF GLAREYGSPL KAYTPVVVTL WYRAPELLLG 600
AKEYSTAVDM WSVGCIFGEL LTQKPLFPGK SDIDQINKIF KDLGTPSEKI WPGYNDLPAV 660
KKMTFSEYPY NNLRKRFGAL LSDQGFDLMN KFLTYYPGRR INAEDGLKHE YFRETPLPID 720
PSMFPTWPAK SEQQRVKRGT SPRPPEGGLG YSQLGDDDLK ETGFHLTTTN QGASAAGPGF 780
SLKF 784 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:EC.
 GO:0006915; P:apoptotic process; IMP:MGI.
 GO:0001824; P:blastocyst development; IMP:MGI.
 GO:0007088; P:regulation of mitosis; IMP:MGI. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS