| Tag | Content |
|---|
| CPLM ID | CPLM-002308 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CAD protein |
Protein Synonyms/Alias | Protein rudimentary; Glutamine-dependent carbamoyl-phosphate synthase; Aspartate carbamoyltransferase; Dihydroorotase |
Gene Name | r |
Gene Synonyms/Alias | CG18572 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1744 | RLTMEDIKRKFHRNP | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). |
Sequence Annotation | DOMAIN 195 380 Glutamine amidotransferase type-1.
DOMAIN 529 721 ATP-grasp 1.
DOMAIN 1066 1257 ATP-grasp 2.
NP_BIND 555 610 ATP (By similarity).
NP_BIND 1092 1149 ATP (By similarity).
REGION 1 369 GATase (Glutamine amidotransferase).
REGION 370 415 Linker.
REGION 416 1470 CPSase (Carbamoyl-phosphate synthase).
REGION 1471 1484 Linker.
REGION 1485 1800 DHOase (dihydroorotase).
REGION 1801 1912 Linker.
REGION 1913 2224 ATCase (Aspartate transcarbamylase).
ACT_SITE 269 269 For GATase activity (By similarity).
ACT_SITE 353 353 For GATase activity (By similarity).
ACT_SITE 355 355 For GATase activity (By similarity).
METAL 678 678 Manganese 1 (By similarity).
METAL 692 692 Manganese 1 (By similarity).
METAL 692 692 Manganese 2 (By similarity).
METAL 694 694 Manganese 2 (By similarity).
METAL 1216 1216 Manganese 3 (By similarity).
METAL 1228 1228 Manganese 3 (By similarity).
METAL 1228 1228 Manganese 4 (By similarity).
METAL 1230 1230 Manganese 4 (By similarity).
METAL 1486 1486 Zinc (Potential).
METAL 1488 1488 Zinc (Potential).
MOD_RES 1883 1883 Phosphoserine.
MOD_RES 1885 1885 Phosphoserine.
MOD_RES 1892 1892 Phosphoserine.
MOD_RES 1894 1894 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Hydrolase; Ligase; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Pyrimidine biosynthesis; Reference proteome; Repeat; Transferase; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2224 AA |
Protein Sequence | MASTDCYLAL EDGTVLPGYS FGYVPSENES KVGFGGEVVF QTGMVGYTEA LTDRSYSGQI 60
LVLTYPLIGN YGVPAPDEDE HGLPLHFEWM KGVVQATALV VGEVAEEAFH WRKWKTLPDW 120
LKQHKVPGIQ DIDTRALTKK LREQGSMLGK IVYEKPPVEG LPKSSFVDPN VRNLAKECSV 180
KERQVYGNPN GKGPRIAILD CGLKLNQLRC LLQRGASVTL LPWSARLEDE QFDALFLSNG 240
PGNPESCDQI VQQVRKVIEE GQKPVFGICL GHQLLAKAIG CSTYKMKYGN RGHNLPCLHR 300
ATGRCLMTSQ NHGYAVDLEQ LPDGWSELFV NANDGTNEGI VHASKPYFSV QFHPEHHAGP 360
QDTEFLFDVF MESIQQKDLT IPQLIEQRLR PTTPAIDSAP VMPRKVLILG SGGLSIGQAG 420
EFDYSGSQAI KAMRESNIQT VLINPNIATV QTSKGMADKC YFLPLTPHYV EQVIKSERPN 480
GVLLTFGGQT ALNCGVQLER AGVFSKYNVR ILGTPIQSII ETEDRKLFAE RVNEIGEQVA 540
PSEAVYSVAQ ALDAASRLGY PVMARAAFSL GGLGSGFANN EEELQSLAQQ ALAHSSQLIV 600
DKSLKGWKEV EYEVVRDAYN NCITVCNMEN FDPLGIHTGE SIVVAPSQTL SDREYQMLRS 660
TALKVIRHFG VVGECNIQYA LCPHSEQYYI IEVNARLSRS SALASKATGY PLAYVAAKLA 720
LGLPLPDIKN SVTGNTTACF EPSLDYCVVK IPRWDLAKFV RVSKHIGSSM KSVGEVMAIG 780
RNFEEAFQKA LRMVDSDVLG FDPDVVPLNK EQLAEQLSEP TDRRPFVIAA ALQLGMSLRE 840
LHQLTNIDYW FLEKLERIIL LQSLLTRNGS RTDAALLLKA KRFGFSDKQI AKYIKSTELA 900
VRHQRQEFGI RPHVKQIDTV AGEWPASTNY LYHTYNGSEH DVDFPGGHTI VVGSGVYRIG 960
SSVEFDWCAV GCLRELRKLQ RPTIMINYNP ETVSTDYDMC DRLYFEEISF EVVMDIYEME 1020
NSEGIILSMG GQLPNNIAMD LHRQQAKVLG TSPESIDCAE NRFKFSRMLD RKGILQPRWK 1080
ELTNLQSAIE FCEEVGYPCL VRPSYVLSGA AMNVAYSNQD LETYLNAASE VSREHPVVIS 1140
KFLTEAKEID VDAVASDGRI LCMAVSEHVE NAGVHSGDAT LVTPPQDLNA ETLEAIKRIT 1200
CDLASVLDVT GPFNMQLIAK NNELKVIECN VRVSRSFPFV SKTLDHDFVA TATRAIVGLD 1260
VEPLDVLHGV GKVGVKVPQF SFSRLAGADV QLGVEMASTG EVACFGDNRY EAYLKAMMST 1320
GFQIPKNAVL LSIGSFKHKM ELLPSIRDLA KMGYKLYASM GTGDFYAEHG VNVESVQWTF 1380
DKTTPDDING ELRHLAEFLA NKQFDLVINL PMSGGGARRV SSFMTHGYRT RRLAVDYSIP 1440
LVTDVKCTKL LVESMRMNGG KPPMKTHTDC MTSRRIVKLP GFIDVHVHLR EPGATHKEDF 1500
ASGTAAALAG GVTLVCAMPN TNPSIVDRET FTQFQELAKA GARCDYALYV GASDDNWAQV 1560
NELASHACGL KMYLNDTFGT LKLSDMTSWQ RHLSHWPKRS PIVCHAERQS TAAVIMLAHL 1620
LDRSVHICHV ARKEEIQLIR SAKEKGVKVT CEVCPHHLFL STKDVERLGH GMSEVRPLLC 1680
SPEDQEALWE NIDYIDVFAT DHAPHTLAEK RSERPPPGFP GVETILPLLL QAVHEGRLTM 1740
EDIKRKFHRN PKIIFNLPDQ AQTYVEVDLD EEWTITGNEM KSKSGWTPFE GTKVKGRVHR 1800
VVLRGEVAFV DGQVLVQPGF GQNVRPKQSP LASEASQDLL PSDNDANDTF TRLLTSEGPG 1860
GGVHGISTKV HFVDGANFLR PNSPSPRIRL DSASNTTLRE YLQRTTNSNP VAHSLMGKHI 1920
LAVDMFNKDH LNDIFNLAQL LKLRGTKDRP VDELLPGKIM ASVFYEVSTR TQCSFAAAML 1980
RLGGRVISMD NITSSVKKGE SLEDSIKVVS SYADVVVLRH PSPGAVARAA TFSRKPLINA 2040
GDGVGEHPTQ ALLDIFTIRE EFGTVNGLTI TMVGDLKNGR TVHSLARLLT LYNVNLQYVA 2100
PNSLQMPDEV VQFVHQRGVK QLFARDLKNV LPDTDVLYMT RIQRERFDNV EDYEKCCGHL 2160
VLTPEHMMRA KKRSIVLHPL PRLNEISREI DSDPRAAYFR QAEYGMYIRM ALLAMVVGGR 2220
NTAL 2224 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016597; F:amino acid binding; IEA:InterPro. GO:0004070; F:aspartate carbamoyltransferase activity; IDA:FlyBase. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IDA:FlyBase. GO:0004151; F:dihydroorotase activity; IDA:FlyBase. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IMP:FlyBase. GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. GO:0070409; P:carbamoyl phosphate biosynthetic process; IEA:InterPro. GO:0006543; P:glutamine catabolic process; IEA:InterPro. GO:0006541; P:glutamine metabolic process; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |