UniProt Accession

 ALDR_RAT; P07943 

Genbank Protein ID

 X05884; M60322; BC062034 

Genbank Nucleotide ID

 CAA29308.1; AAA40721.1; AAH62034.1 

Protein Name

 Aldose reductase 

Protein Synonyms/Alias

 AR; Aldehyde reductase 

Gene Name

 Akr1b1 

Gene Synonyms/Alias

 Akr1b4; Aldr1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
12	LELNNGTKMPTLGLG	acetylation	[1]
53	AQVYQNEKEVGVALQ	acetylation	[1]
222	SPDRPWAKPEDPSLL	acetylation	[1]
240	RIKEIAAKYNKTTAQ	acetylation	[1]
263	RNLVVIPKSVTPARI	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. 

Sequence Annotation

 NP_BIND 10 19 NADP (Potential).
 NP_BIND 211 273 NADP (By similarity).
 ACT_SITE 49 49 Proton donor (By similarity).
 BINDING 111 111 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 95 95 N6-acetyllysine (By similarity).
 MOD_RES 222 222 N6-acetyllysine (By similarity).
 MOD_RES 263 263 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:RGD.
 GO:0046427; P:positive regulation of JAK-STAT cascade; IMP:RGD.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
 GO:0010033; P:response to organic substance; IDA:RGD.
 GO:0006061; P:sorbitol biosynthetic process; IMP:RGD.
 GO:0031098; P:stress-activated protein kinase signaling cascade; IMP:RGD. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 

PRINTS

 PR00069; ALDKETRDTASE.