CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011718
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ethylene receptor 2 
Protein Synonyms/Alias
 AtETR2; Protein ETHYLENE RESPONSE 2; Protein ETR2 
Gene Name
 ETR2 
Gene Synonyms/Alias
 At3g23150; K14B15.9 
Created Date
 July 27, 2013 
Organism
 Arabidopsis thaliana (Mouse-ear cress) 
NCBI Taxa ID
 3702 
Lysine Modification
Position
Peptide
Type
References
507EGSSLMFKVLKERGSacetylation[1]
751GINGVVRKPVVLRAMubiquitination[2]
Reference
 [1] Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis.
 Finkemeier I, Laxa M, Miguet L, Howden AJ, Sweetlove LJ.
 Plant Physiol. 2011 Apr;155(4):1779-90. [PMID: 21311031]
 [2] Multidimensional protein identification technology (MudPIT) analysis of ubiquitinated proteins in plants.
 Maor R, Jones A, Nühse TS, Studholme DJ, Peck SC, Shirasu K.
 Mol Cell Proteomics. 2007 Apr;6(4):601-10. [PMID: 17272265] 
Functional Description
 Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling. 
Sequence Annotation
 DOMAIN 187 331 GAF.
 DOMAIN 374 614 Histidine kinase.
 DOMAIN 647 766 Response regulatory.
 METAL 94 94 Copper (By similarity).
 METAL 98 98 Copper (By similarity).
 MOD_RES 702 702 4-aspartylphosphate (By similarity).
 DISULFID 32 32 Interchain (By similarity).
 DISULFID 34 34 Interchain (By similarity).
 CROSSLNK 751 751 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 ATP-binding; Complete proteome; Copper; Disulfide bond; Endoplasmic reticulum; Ethylene signaling pathway; Isopeptide bond; Kinase; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase; Transmembrane; Transmembrane helix; Two-component regulatory system; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 773 AA 
Protein Sequence
MVKEIASWLL ILSMVVFVSP VLAINGGGYP RCNCEDEGNS FWSTENILET QRVSDFLIAV 60
AYFSIPIELL YFVSCSNVPF KWVLFEFIAF IVLCGMTHLL HGWTYSAHPF RLMMAFTVFK 120
MLTALVSCAT AITLITLIPL LLKVKVREFM LKKKAHELGR EVGLILIKKE TGFHVRMLTQ 180
EIRKSLDRHT ILYTTLVELS KTLGLQNCAV WMPNDGGTEM DLTHELRGRG GYGGCSVSME 240
DLDVVRIRES DEVNVLSVDS SIARASGGGG DVSEIGAVAA IRMPMLRVSD FNGELSYAIL 300
VCVLPGGTPR DWTYQEIEIV KVVADQVTVA LDHAAVLEES QLMREKLAEQ NRALQMAKRD 360
ALRASQARNA FQKTMSEGMR RPMHSILGLL SMIQDEKLSD EQKMIVDTMV KTGNVMSNLV 420
GDSMDVPDGR FGTEMKPFSL HRTIHEAACM ARCLCLCNGI RFLVDAEKSL PDNVVGDERR 480
VFQVILHIVG SLVKPRKRQE GSSLMFKVLK ERGSLDRSDH RWAAWRSPAS SADGDVYIRF 540
EMNVENDDSS SQSFASVSSR DQEVGDVRFS GGYGLGQDLS FGVCKKVVQL IHGNISVVPG 600
SDGSPETMSL LLRFRRRPSI SVHGSSESPA PDHHAHPHSN SLLRGLQVLL VDTNDSNRAV 660
TRKLLEKLGC DVTAVSSGFD CLTAIAPGSS SPSTSFQVVV LDLQMAEMDG YEVAMRIRSR 720
SWPLIVATTV SLDEEMWDKC AQIGINGVVR KPVVLRAMES ELRRVLLQAD QLL 773 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051740; F:ethylene binding; IDA:TAIR.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
 GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; TAS:TAIR.
 GO:0004872; F:receptor activity; TAS:TAIR.
 GO:0009873; P:ethylene mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:GOC.
 GO:0010105; P:negative regulation of ethylene mediated signaling pathway; TAS:TAIR.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC. 
Interpro
 IPR011006; CheY-like_superfamily.
 IPR003018; GAF.
 IPR003594; HATPase_ATP-bd.
 IPR014525; Sig_transdc_His_kin_hyb_Et-sen.
 IPR003661; Sig_transdc_His_kin_sub1_dim/P.
 IPR009082; Sig_transdc_His_kinase_dimeric.
 IPR001789; Sig_transdc_resp-reg_receiver. 
Pfam
 PF01590; GAF
 PF00512; HisKA
 PF00072; Response_reg 
SMART
 SM00065; GAF
 SM00387; HATPase_c
 SM00388; HisKA
 SM00448; REC 
PROSITE
 PS50109; HIS_KIN
 PS50110; RESPONSE_REGULATORY 
PRINTS