UniProt Accession

 GPM6B_MOUSE; P35803; A2AEG4; Q8R3J6; Q99L14; Q9D4F5; Q9JHG9; Q9JHI1; Q9JHK2; Q9JI62; Q9JI63; Q9JI64; Q9JI65 

Genbank Protein ID

 S65737; AF254869; AF254870; AF254871; AF254872; AF254873; AF254874; AF254875; AF254876; AF254877; AF254878; AF254879; AK016567; AL671905; BC003912; BC025165 

Genbank Nucleotide ID

 AAB28351.1; AAF87987.1; AAF87988.1; AAF87989.1; AAF87990.1; AAF87991.1; AAF87992.1; AAF87993.1; AAF87994.1; AAF87995.1; AAF87996.1; AAF87997.1; BAB30309.1; CAM18328.1; AAH03912.1; AAH25165.1 

Protein Name

 Neuronal membrane glycoprotein M6-b 

Protein Synonyms/Alias

 M6b 

Gene Name

 Gpm6b 

Gene Synonyms/Alias

 M6b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
2	******MKPAMETAA	ubiquitination	[1]
298	AYLKDASKMQAYQDI	ubiquitination	[1]
306	MQAYQDIKAKEEQEL	ubiquitination	[1]
308	AYQDIKAKEEQELQD	ubiquitination	[1]
321	QDIQSRSKEQLNSYT	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. 

Sequence Annotation

 MOD_RES 320 320 Phosphoserine.
 CARBOHYD 113 113 N-linked (GlcNAc...) (Potential).
 CARBOHYD 217 217 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Osteogenesis; Phosphoprotein; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 328 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0085029; P:extracellular matrix assembly; ISS:UniProtKB.
 GO:2000009; P:negative regulation of protein localization to cell surface; IDA:UniProtKB.
 GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
 GO:0001503; P:ossification; IEA:UniProtKB-KW.
 GO:0030501; P:positive regulation of bone mineralization; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.
 GO:0051893; P:regulation of focal adhesion assembly; ISS:UniProtKB. 

Interpro

 IPR001614; Myelin_PLP.
 IPR018237; Myelin_PLP_CS. 

Pfam

 PF01275; Myelin_PLP 

SMART

 SM00002; PLP 

PROSITE

 PS00575; MYELIN_PLP_1
 PS01004; MYELIN_PLP_2 

PRINTS

 PR00214; MYELINPLP.