| Tag | Content |
|---|
| CPLM ID | CPLM-013020 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sulfhydryl oxidase 2 |
Protein Synonyms/Alias | Quiescin Q6-like protein 1 |
Gene Name | Qsox2 |
Gene Synonyms/Alias | Qscn6l1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 289 | SLPDVRKKSLFLPEK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity). |
Sequence Annotation | DOMAIN 54 172 Thioredoxin.
DOMAIN 415 524 ERV/ALR sulfhydryl oxidase.
NP_BIND 499 506 FAD (By similarity).
ACT_SITE 85 85 Nucleophile (By similarity).
ACT_SITE 88 88 Nucleophile (By similarity).
BINDING 420 420 FAD (By similarity).
BINDING 427 427 FAD (By similarity).
BINDING 431 431 FAD (By similarity).
BINDING 472 472 FAD (By similarity).
BINDING 476 476 FAD (By similarity).
BINDING 521 521 FAD (By similarity).
BINDING 524 524 FAD (By similarity).
CARBOHYD 71 71 N-linked (GlcNAc...) (Potential).
CARBOHYD 172 172 N-linked (GlcNAc...) (Potential).
CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
CARBOHYD 260 260 N-linked (GlcNAc...) (Potential).
DISULFID 85 88 Redox-active (By similarity).
DISULFID 412 424 By similarity.
DISULFID 470 473 By similarity.
DISULFID 530 533 By similarity. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; FAD; Flavoprotein; Glycoprotein; Membrane; Oxidoreductase; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 692 AA |
Protein Sequence | MAAARAVARD PGAYARQPPS LRAARLPRLL FLLAVVAAVG PREGGGARLY REGSDAVWLL 60
DSGSVRSATG NSSAAWLVQF HSSWCGHCIG YAPTWRALAA DVRDWAAAIR VAALDCAEEK 120
NQDVCRTYDI HFYPTFRYFK AFTKEFTTGE NFKGPDRELR TVRQTMIDFL QNHTEGTWPP 180
ACPPLDPIQS SDILSFMDSH SGQYHAIVFE SNGSYVGREV ILDLIPYENI MVSRALDTDK 240
AFLGTLGITS VPSCYLIYPN GSHGLVNVAK PLRSFFSSHL KSLPDVRKKS LFLPEKSNKE 300
EKSEVVVWKE FDRAKLYTAD LESGLHYLLR VELAAHRSLA GAQLKTFRDF VTVVAKLFPG 360
RPAVKKLLET LQEWLANLPL DKIPYNAILD LVNNKMQISG IFLTSHVKWV GCQGSRLELR 420
GYPCSLWKLF HTLTVQASTH PEALAGTGFE GHPQAVLQAI RRYIRTFFGC KECGEHFEEM 480
AKESMDSVKT PDQAVLWLWR KHNMVNSRLA GHLSEDPKFP KVPWPTPDLC PACHEEIKGL 540
DSWNEGQVLL FLKQHYSRDN LVDAYSVDQG SPGEWEAQGR EQEEGKGLNP SGKSWRHHDT 600
GSLRPPHILG PRTDLSKSLH HRLDLRLQSP QGPQALKEAK AVVPFLGVGF SSLDMSLCVV 660
LYVASSLFLM IMYFFFRVRS KRWKVRLYHP AV 692 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016972; F:thiol oxidase activity; IEA:EC. GO:0045454; P:cell redox homeostasis; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |