| Tag | Content |
|---|
| CPLM ID | CPLM-022625 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase makorin-1 |
Protein Synonyms/Alias | |
Gene Name | Mkrn1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 351 | SEYWVEEKEEKQKLI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase (By similarity). Has negative and positive effects on RNA polymerase II-dependent transcription. |
Sequence Annotation | ZN_FING 55 82 C3H1-type 1.
ZN_FING 84 111 C3H1-type 2.
ZN_FING 208 235 C3H1-type 3.
ZN_FING 281 335 RING-type.
ZN_FING 364 393 C3H1-type 4.
REGION 236 263 Makorin-type Cys-His. |
Keyword | Alternative splicing; Complete proteome; Ligase; Metal-binding; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 481 AA |
Protein Sequence | MAEAAAPGTT ATTSGAGAAA AAVAAASLTS IPTVAAPSPG AGGGGGGSDG SGGGWTKQVT 60
CRYFMHGVCK EGDNCRYSHD LSDSPYGVVC KYFQRGYCVY GDRCRYEHSK PLKQEEVTAT 120
DLSAKPSLAA SSSLSSGVGS LAEMNSGEAE SRNPSFPTVG AGSEDWVNAI EFVPGQPYCG 180
RTAPSCTEVP PQGSVTKEES EKEPTTVETK KQLCPYAAVG ECRYGENCVY LHGDSCDMCG 240
LQVLHPVDAA QRSQHIKSCI EAHEKDMELS FAVQRTKDMV CGICMEVVYE KANPSERRFG 300
ILSNCNHTYC LKCIRKWRSA KQFESKIIKS CPECRITSNF VIPSEYWVEE KEEKQKLIQK 360
YKEAMSNKAC RYFDEGRGSC PFGGNCFYKH AYPDGRREEP QRQKVGTSSR YRAQRRSHFW 420
ELIEERENNP FDNDEEEVVT FELGEMLLML LAAGGDDELT DSEDEWDLFH DELEDFYDLD 480
L 481 |
Gene Ontology | GO:0003682; F:chromatin binding; IDA:MGI. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |