| Tag | Content |
|---|
| CPLM ID | CPLM-015794 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Heparan sulfate 2-O-sulfotransferase 1 |
Protein Synonyms/Alias | 2-O-sulfotransferase; 2OST |
Gene Name | HS2ST1 |
Gene Synonyms/Alias | HS2ST; KIAA0448 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 101 | YDLCAKNKYHVLHIN | ubiquitination | [1] | | 126 | QDQVRFVKNITSWKE | ubiquitination | [1] | | 303 | PTKQTIAKLQQSDIW | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). |
Sequence Annotation | ACT_SITE 140 140 By similarity.
CARBOHYD 108 108 N-linked (GlcNAc...) (Potential).
CARBOHYD 127 127 N-linked (GlcNAc...) (Potential).
DISULFID 201 209 By similarity.
DISULFID 222 228 By similarity. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 356 AA |
Protein Sequence | MGLLRIMMPP KLQLLAVVAF AVAMLFLENQ IQKLEESRSK LERAIARHEV REIEQRHTMD 60
GPRQDATLDE EEDMVIIYNR VPKTASTSFT NIAYDLCAKN KYHVLHINTT KNNPVMSLQD 120
QVRFVKNITS WKEMKPGFYH GHVSYLDFAK FGVKKKPIYI NVIRDPIERL VSYYYFLRFG 180
DDYRPGLRRR KQGDKKTFDE CVAEGGSDCA PEKLWLQIPF FCGHSSECWN VGSRWAMDQA 240
KYNLINEYFL VGVTEELEDF IMLLEAALPR FFRGATELYR TGKKSHLRKT TEKKLPTKQT 300
IAKLQQSDIW KMENEFYEFA LEQFQFIRAH AVREKDGDLY ILAQNFFYEK IYPKSN 356 |
Gene Ontology | GO:0000139; C:Golgi membrane; TAS:Reactome. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0008146; F:sulfotransferase activity; IEA:InterPro. GO:0005975; P:carbohydrate metabolic process; TAS:Reactome. GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:Reactome. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |