UniProt Accession

 SRLD_ECOLI; P05707 

Genbank Protein ID

 J02708; U29579; U00096; AP009048 

Genbank Nucleotide ID

 AAC13413.1; AAA69214.1; AAC75747.1; BAA16566.1 

Protein Name

 Sorbitol-6-phosphate 2-dehydrogenase 

Protein Synonyms/Alias

 Glucitol-6-phosphate dehydrogenase; Ketosephosphate reductase 

Gene Name

 srlD 

Gene Synonyms/Alias

 gutD; b2705; JW2674 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
142	RIIQINSKSGKVGSK	acetylation	[1]
218	VEQYYIDKVPLKRGC	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

  

Sequence Annotation

 NP_BIND 4 33 NAD (By similarity).
 ACT_SITE 154 154 Proton acceptor (By similarity).
 BINDING 141 141 Substrate (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 259 AA 

Protein Sequence

Gene Ontology

 GO:0009010; F:sorbitol-6-phosphate 2-dehydrogenase activity; IEA:EC.
 GO:0006062; P:sorbitol catabolic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.