UniProt Accession

 TRI59_HUMAN; Q8IWR1; A8K5G9; D3DNL9 

Genbank Protein ID

 AY159379; AK291284; CH471052; CH471052; CH471052; CH471052; BC109259; BC109260 

Genbank Nucleotide ID

 AAN86853.1; BAF83973.1; EAW78635.1; EAW78636.1; EAW78637.1; EAW78638.1; AAI09260.1; AAI09261.1 

Protein Name

 Tripartite motif-containing protein 59 

Protein Synonyms/Alias

 RING finger protein 104; Tumor suppressor TSBF-1 

Gene Name

 TRIM59 

Gene Synonyms/Alias

 RNF104; TRIM57; TSBF1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
176	EQKSHSEKMIQGDKE	ubiquitination	[1]
253	SPLKFLEKVDDVRQH	ubiquitination	[1]
298	RTEIGQIKNVLIPKM	acetylation	[2]
298	RTEIGQIKNVLIPKM	ubiquitination	[1]
304	IKNVLIPKMKISPKR	acetylation	[2]
306	NVLIPKMKISPKRMS	acetylation	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 

Functional Description

  

Sequence Annotation

 ZN_FING 10 60 RING-type.
 ZN_FING 92 134 B box-type.  

Keyword

 Coiled coil; Complete proteome; Membrane; Metal-binding; Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 403 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IMP:MGI. 

Interpro

 IPR000315; Znf_B-box.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 

Pfam

 PF00643; zf-B_box 

SMART

 SM00184; RING 

PROSITE

 PS50119; ZF_BBOX
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS