CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028634
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Stomatin-like protein 2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Stoml2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
68LRIMDPYKASYGVEDacetylation[1]
99LGKLSLDKVFRERESacetylation[2, 3, 4, 5]
99LGKLSLDKVFRERESsuccinylation[4]
175AINVAEGKKQAQILAacetylation[4, 5]
175AINVAEGKKQAQILAsuccinylation[4]
187ILASEAEKAEQINQAacetylation[1, 3, 4, 5, 6, 7]
187ILASEAEKAEQINQAsuccinylation[4]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [7] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 286 AA 
Protein Sequence
MLARAARGTG ALLLRGLNVL IPVLDRIRYV QSLKEIVINV PEQSAVTLDN VTLQIDGVLY 60
LRIMDPYKAS YGVEDPEYAV TQLAQTTMRS ELGKLSLDKV FRERESLNAN IVDAINQAAD 120
CWGIRCLRYE IKDIHVPPRV KESMQMQVEA ERRKRATVLE SEGTRESAIN VAEGKKQAQI 180
LASEAEKAEQ INQAAGEASA VLAKAKAKAE AIRILAGALT QHNGDAAASL TVAEQYVSAF 240
SKLAKDSNTV LLPSNPSDVT SMVAQAMGVY GALTKAPVPG AQNSSQ 286 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI. 
Interpro
 IPR001107; Band_7.
 IPR001972; Stomatin. 
Pfam
 PF01145; Band_7 
SMART
 SM00244; PHB 
PROSITE
  
PRINTS
 PR00721; STOMATIN.