UniProt Accession

 B4E1F4_HUMAN; B4E1F4 

Genbank Protein ID

 AL121753; AL135844; AL356652; AK303816 

Genbank Nucleotide ID

 BAG64766.1 

Protein Name

 ER degradation-enhancing alpha-mannosidase-like protein 2 

Protein Synonyms/Alias

 cDNA FLJ61531, highly similar to ER degradation-enhancingalpha-mannosidase-like 2 

Gene Name

 EDEM2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
126	DAVESIEKISKVECG	ubiquitination	[1]
129	ESIEKISKVECGFAT	ubiquitination	[2]
216	LHCCQRLKEEQWEVE	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 302 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IEA:InterPro. 

Interpro

 IPR001382; Glyco_hydro_47. 

Pfam

 PF01532; Glyco_hydro_47 

SMART

  

PROSITE

  

PRINTS

 PR00747; GLYHDRLASE47.