| Tag | Content |
|---|
| CPLM ID | CPLM-023221 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquilin-1 |
Protein Synonyms/Alias | Protein linking IAP with cytoskeleton 1; PLIC-1; hPLIC-1 |
Gene Name | UBQLN1 |
Gene Synonyms/Alias | DA41; PLIC1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 45 | KVTVKTPKEKEEFAV | ubiquitination | [1] | | 47 | TVKTPKEKEEFAVPE | ubiquitination | [1, 2] | | 62 | NSSVQQFKEEISKRF | ubiquitination | [1] | | 67 | QFKEEISKRFKSHTD | ubiquitination | [1] | | 70 | EEISKRFKSHTDQLV | ubiquitination | [1] | | 83 | LVLIFAGKILKDQDT | ubiquitination | [1, 2] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI. J Proteome Res. 2012 Feb 3;11(2):796-807. [ PMID: 22053931] |
Functional Description | Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation. |
Sequence Annotation | DOMAIN 37 111 Ubiquitin-like.
DOMAIN 546 586 UBA.
MOD_RES 2 2 N-acetylalanine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Proteasome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 589 AA |
Protein Sequence | MAESGESGGP PGSQDSAAGA EGAGAPAAAA SAEPKIMKVT VKTPKEKEEF AVPENSSVQQ 60
FKEEISKRFK SHTDQLVLIF AGKILKDQDT LSQHGIHDGL TVHLVIKTQN RPQDHSAQQT 120
NTAGSNVTTS STPNSNSTSG SATSNPFGLG GLGGLAGLSS LGLNTTNFSE LQSQMQRQLL 180
SNPEMMVQIM ENPFVQSMLS NPDLMRQLIM ANPQMQQLIQ RNPEISHMLN NPDIMRQTLE 240
LARNPAMMQE MMRNQDRALS NLESIPGGYN ALRRMYTDIQ EPMLSAAQEQ FGGNPFASLV 300
SNTSSGEGSQ PSRTENRDPL PNPWAPQTSQ SSSASSGTAS TVGGTTGSTA SGTSGQSTTA 360
PNLVPGVGAS MFNTPGMQSL LQQITENPQL MQNMLSAPYM RSMMQSLSQN PDLAAQMQNP 420
DTLSAMSNPR AMQALLQIQQ GLQTLATEAP GLIPGFTPGL GALGSTGGSS GTNGSNATPS 480
ENTSPTAGTT EPGHQQFIQQ MLQALAGVNP QLQNPEVRFQ QQLEQLSAMG FLNREANLQA 540
LIATGGDINA AIERLLGSQP S 561 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:HGNC. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0048471; C:perinuclear region of cytoplasm; NAS:UniProtKB. GO:0000502; C:proteasome complex; IEA:UniProtKB-KW. GO:0043234; C:protein complex; IDA:LIFEdb. GO:0071456; P:cellular response to hypoxia; IMP:BHF-UCL. GO:0097194; P:execution phase of apoptosis; IMP:BHF-UCL. GO:0031396; P:regulation of protein ubiquitination; IDA:HGNC. GO:0034976; P:response to endoplasmic reticulum stress; IMP:BHF-UCL. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |