| Tag | Content |
|---|
| CPLM ID | CPLM-011454 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphatidylinositol transfer protein CSR1 |
Protein Synonyms/Alias | CHS5 SPA2 rescue protein 1; SEC14 homolog protein 2 |
Gene Name | CSR1 |
Gene Synonyms/Alias | SFH2; YLR380W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 342 | ETRAMIEKEREELVE | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Activates SPO14/PLD1 (phospholipase D1) by stimulating phosphoinositide synthesis via the STT4 PtdIns 4-kinase. Modulates ArfGAP function through effects on SPO14 activity. Inhibits phosphatidylcholine degradation by PLB1 (phospholipase B1). May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress. |
Sequence Annotation | DOMAIN 157 317 CRAL-TRIO.
MOD_RES 2 2 N-acetylserine.
MOD_RES 2 2 Phosphoserine. |
Keyword | Acetylation; Complete proteome; Cytoplasm; Endosome; Lipid degradation; Lipid metabolism; Lipid transport; Phospholipid degradation; Phospholipid metabolism; Phosphoprotein; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 408 AA |
Protein Sequence | MSFDRQLTED QEVVLKQIWT HLFHLWQVPV DGTHIFPNNS LHSSSTPAKK KKSSWFSKLQ 60
SSDHTQDSSE AAEAAHLYEK GKIHKALANL DPQTTKKQFW HDIKNETPDA TILKFIRARK 120
WNADKTIAML GHDLYWRKDT INKIINGGER AVYENNETGV IKNLELQKAT IQGYDNDMRP 180
VILVRPRLHH SSDQTEQELE KFSLLVIEQS KLFFKENYPA STTILFDLNG FSMSNMDYAP 240
VKFLITCFEA HYPESLGHLL IHKAPWIFNP IWNIIKNWLD PVVASKIVFT KNIDELHKFI 300
QPQYIPRYLG GENDNDLDHY TPPDGSLDVH LKDTETRAMI EKEREELVEQ FLTVTAQWIE 360
HQPLNDPAYI QLQEKRVQLS TALCENYSKL DPYIRSRSVY DYNGSLKV 408 |
Gene Ontology | GO:0005829; C:cytosol; IDA:SGD. GO:0005768; C:endosome; IDA:SGD. GO:0005811; C:lipid particle; IDA:SGD. GO:0005739; C:mitochondrion; IDA:SGD. GO:0008526; F:phosphatidylinositol transporter activity; IDA:SGD. GO:0043001; P:Golgi to plasma membrane protein transport; IGI:SGD. GO:0045717; P:negative regulation of fatty acid biosynthetic process; IDA:SGD. GO:1901352; P:negative regulation of phosphatidylglycerol biosynthetic process; IGI:SGD. GO:0046488; P:phosphatidylinositol metabolic process; IGI:SGD. GO:0009395; P:phospholipid catabolic process; IEA:UniProtKB-KW. GO:2001247; P:positive regulation of phosphatidylcholine biosynthetic process; IGI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |